Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps
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Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps. / Frendø, Martin; Håkansson, Kåre; Schwer, Susanne; Rix, Iben; Ravn, Andreas T.; Backer, Vibeke; von Buchwald, Christian.
I: American Journal of Rhinology & Allergy, Bind 30, Nr. 3, 05.2016, s. e67-e71.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps
AU - Frendø, Martin
AU - Håkansson, Kåre
AU - Schwer, Susanne
AU - Rix, Iben
AU - Ravn, Andreas T.
AU - Backer, Vibeke
AU - von Buchwald, Christian
PY - 2016/5
Y1 - 2016/5
N2 - BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder associated with asthma. This association is well described in patients with CRSwNP undergoing endoscopic sinus surgery (ESS); however, some patients are never referred for surgery, and the frequency of asthma in this group is largely unknown.OBJECTIVE: To determine the frequency of asthma in patients with CRSwNP treated in a primary care (PC) setting who have never been referred for surgery and to compare this with ESS patients.METHODS: Fifty-seven patients with CRSwNP who had never undergone ESS were prospectively recruited from nine PC ear, nose, and throat clinics in the Copenhagen area. CRSwNP was diagnosed according to the European Position Paper on Chronic Rhinosinusitis and Nasal Polyps; severity was assessed by using a visual analog scale. Allergy, lung function, and asthma tests (reversibility to β2-agonist, peak expiratory flow variability, and mannitol challenge) were performed. Findings were compared with our previously published data from patients with CRSwNP referred for surgery.RESULTS: Asthma was diagnosed in 25 patients (44%) based on respiratory symptoms and a positive asthma test; of these, 12 (48%) had undiagnosed asthma prior to study onset. Furthermore, when using the same methods, we found a lower frequency of asthma in PC patients compared with ESS patients (44% versus 65%, p = 0.04).CONCLUSION: A high prevalence of asthma in PC patients with CRSwNP was found. Frequently, asthma was undiagnosed. However, asthma was significantly less prevalent in PC patients compared with patients referred for ESS. The frequent concomitance of asthma, i.e., united airways disease, in PC patients calls for closer collaboration between ear, nose, and throat specialists, and asthma specialists.
AB - BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder associated with asthma. This association is well described in patients with CRSwNP undergoing endoscopic sinus surgery (ESS); however, some patients are never referred for surgery, and the frequency of asthma in this group is largely unknown.OBJECTIVE: To determine the frequency of asthma in patients with CRSwNP treated in a primary care (PC) setting who have never been referred for surgery and to compare this with ESS patients.METHODS: Fifty-seven patients with CRSwNP who had never undergone ESS were prospectively recruited from nine PC ear, nose, and throat clinics in the Copenhagen area. CRSwNP was diagnosed according to the European Position Paper on Chronic Rhinosinusitis and Nasal Polyps; severity was assessed by using a visual analog scale. Allergy, lung function, and asthma tests (reversibility to β2-agonist, peak expiratory flow variability, and mannitol challenge) were performed. Findings were compared with our previously published data from patients with CRSwNP referred for surgery.RESULTS: Asthma was diagnosed in 25 patients (44%) based on respiratory symptoms and a positive asthma test; of these, 12 (48%) had undiagnosed asthma prior to study onset. Furthermore, when using the same methods, we found a lower frequency of asthma in PC patients compared with ESS patients (44% versus 65%, p = 0.04).CONCLUSION: A high prevalence of asthma in PC patients with CRSwNP was found. Frequently, asthma was undiagnosed. However, asthma was significantly less prevalent in PC patients compared with patients referred for ESS. The frequent concomitance of asthma, i.e., united airways disease, in PC patients calls for closer collaboration between ear, nose, and throat specialists, and asthma specialists.
KW - Adult
KW - Aged
KW - Asthma
KW - Chronic Disease
KW - Denmark
KW - Ear
KW - Endoscopy
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Nasal Polyps
KW - Nose
KW - Pharynx
KW - Prevalence
KW - Primary Health Care
KW - Prospective Studies
KW - Rhinitis
KW - Sinusitis
KW - Young Adult
KW - Journal Article
KW - Observational Study
U2 - 10.2500/ajra.2016.30.4304
DO - 10.2500/ajra.2016.30.4304
M3 - Journal article
C2 - 27216338
VL - 30
SP - e67-e71
JO - American Journal of Rhinology & Allergy
JF - American Journal of Rhinology & Allergy
SN - 1945-8924
IS - 3
ER -
ID: 173811373