Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish. / Akram, F.; Fuchs, D.; Daue, M.; Nijjar, G.; Ryan, A.; Benros, M. E.; Okusaga, O.; Baca-Garcia, E.; Brenner, L. A.; Lowry, C. A.; Ryan, K. A.; Pavlovich, M.; Mitchell, B. D.; Snitker, S.; Postolache, T. T.
I: Obesity Science and Practice, Bind 4, Nr. 5, 2018, s. 468-476.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish
AU - Akram, F.
AU - Fuchs, D.
AU - Daue, M.
AU - Nijjar, G.
AU - Ryan, A.
AU - Benros, M. E.
AU - Okusaga, O.
AU - Baca-Garcia, E.
AU - Brenner, L. A.
AU - Lowry, C. A.
AU - Ryan, K. A.
AU - Pavlovich, M.
AU - Mitchell, B. D.
AU - Snitker, S.
AU - Postolache, T. T.
PY - 2018
Y1 - 2018
N2 - Objectives: Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods: Fasting nitrite levels were measured in 116 Old Order Amish (78% women). We performed age-and-sex-adjusted ancovas to compare nitrite levels between three groups (a) overweight/obese(−)MetS(−), (b) overweight/obese(+)MetS(−) and (c) overweight/obese(+)MetS)(+). Multivariate linear regressions were conducted on nitrite associations with continuous metabolic variables, with successive adjustments for demographics, body mass index, C-reactive protein and neopterin. Results: Nitrite levels were higher in the obese/overweight(+)MetS(+) group than in the other two groups (p < 0.001). Nitrites were positively associated with levels of triglycerides (p < 0.0001), total cholesterol (p = 0.048), high-density lipoprotein/cholesterol ratio (p < 0.0001) and fasting glucose (p < 0.0001), and negatively correlated with high-density lipoprotein-cholesterol (p < 0.0001). These associations were robust to adjustments for body mass index and inflammatory markers. Conclusion: Further investigation of the connection between obesity/MetS and plasma nitrite levels may lead to novel dietary and pharmacological approaches that ultimately may contribute to reducing the increasing burden of obesity, MetS and cardiovascular morbidity and mortality.
AB - Objectives: Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods: Fasting nitrite levels were measured in 116 Old Order Amish (78% women). We performed age-and-sex-adjusted ancovas to compare nitrite levels between three groups (a) overweight/obese(−)MetS(−), (b) overweight/obese(+)MetS(−) and (c) overweight/obese(+)MetS)(+). Multivariate linear regressions were conducted on nitrite associations with continuous metabolic variables, with successive adjustments for demographics, body mass index, C-reactive protein and neopterin. Results: Nitrite levels were higher in the obese/overweight(+)MetS(+) group than in the other two groups (p < 0.001). Nitrites were positively associated with levels of triglycerides (p < 0.0001), total cholesterol (p = 0.048), high-density lipoprotein/cholesterol ratio (p < 0.0001) and fasting glucose (p < 0.0001), and negatively correlated with high-density lipoprotein-cholesterol (p < 0.0001). These associations were robust to adjustments for body mass index and inflammatory markers. Conclusion: Further investigation of the connection between obesity/MetS and plasma nitrite levels may lead to novel dietary and pharmacological approaches that ultimately may contribute to reducing the increasing burden of obesity, MetS and cardiovascular morbidity and mortality.
KW - Metabolic syndrome
KW - NO
KW - Old Order Amish
KW - plasma nitrite
U2 - 10.1002/osp4.290
DO - 10.1002/osp4.290
M3 - Journal article
C2 - 30338117
AN - SCOPUS:85070298972
VL - 4
SP - 468
EP - 476
JO - Obesity Science & Practice
JF - Obesity Science & Practice
SN - 2055-2238
IS - 5
ER -
ID: 243307597