Association between obesity and asthma in a twin cohort
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.
Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.
Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).
Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.
Udgivelsesdato: Oct.
Originalsprog | Engelsk |
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Tidsskrift | Allergy. European Journal of Allergy and Clinical Immunology |
Vol/bind | 62 |
Udgave nummer | 10 |
Sider (fra-til) | 1199-1204 |
Antal sider | 5 |
ISSN | 0105-4538 |
DOI | |
Status | Udgivet - 2007 |
ID: 4043124