Association between obesity and asthma in a twin cohort
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Association between obesity and asthma in a twin cohort. / Thomsen, SF; Ulrik, Charlotte Suppli; Kyvik, KO; Sørensen, Thorkild I.A.; Posthuma, D; Skadhauge, LR; Steffensen, I; Backer, V.
I: Allergy. European Journal of Allergy and Clinical Immunology, Bind 62, Nr. 10, 2007, s. 1199-1204.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between obesity and asthma in a twin cohort
AU - Thomsen, SF
AU - Ulrik, Charlotte Suppli
AU - Kyvik, KO
AU - Sørensen, Thorkild I.A.
AU - Posthuma, D
AU - Skadhauge, LR
AU - Steffensen, I
AU - Backer, V
PY - 2007
Y1 - 2007
N2 - Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.
AB - Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.
U2 - http://dx.doi.org/10.1111/j.1398-9995.2007.01480.x
DO - http://dx.doi.org/10.1111/j.1398-9995.2007.01480.x
M3 - Journal article
VL - 62
SP - 1199
EP - 1204
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 10
ER -
ID: 4043124