Association between GLP-1 receptor gene polymorphisms with reward Learning, anhedonia, and depression diagnosis
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Association between GLP-1 receptor gene polymorphisms with reward Learning, anhedonia, and depression diagnosis. / Eser, Hale Yapici; Appadurai, Vivek; Eren, Candan Yasemin; Yazici, Dilek; Chen, Chia Yen; Ongur, Dost; Pizzagalli, Diego A.; Werge, Thomas; Hall, Mei Hua.
I: Acta Neuropsychiatrica, Bind 32, Nr. 4, 2020, s. 218-225.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Association between GLP-1 receptor gene polymorphisms with reward Learning, anhedonia, and depression diagnosis
AU - Eser, Hale Yapici
AU - Appadurai, Vivek
AU - Eren, Candan Yasemin
AU - Yazici, Dilek
AU - Chen, Chia Yen
AU - Ongur, Dost
AU - Pizzagalli, Diego A.
AU - Werge, Thomas
AU - Hall, Mei Hua
PY - 2020
Y1 - 2020
N2 - Background:Glucagon-like peptide-1 receptors (GLP-1R) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.Methods:Objective (response bias assessed by the Probabilistic Reward Task (PRT)) and subjective (Snaith-Hamilton Pleasure Scale (SHAPS)) measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.Results:The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC MDD data showed no association between rs1042044 and depression diagnosis.Conclusion:Findings suggest a possible association of rs1042044 with anhedonia, but no association with depression diagnosis.
AB - Background:Glucagon-like peptide-1 receptors (GLP-1R) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.Methods:Objective (response bias assessed by the Probabilistic Reward Task (PRT)) and subjective (Snaith-Hamilton Pleasure Scale (SHAPS)) measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.Results:The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC MDD data showed no association between rs1042044 and depression diagnosis.Conclusion:Findings suggest a possible association of rs1042044 with anhedonia, but no association with depression diagnosis.
KW - anhedonia
KW - depression
KW - GLP-1, polymorphism
KW - reward
U2 - 10.1017/neu.2020.14
DO - 10.1017/neu.2020.14
M3 - Journal article
C2 - 32213216
AN - SCOPUS:85082338231
VL - 32
SP - 218
EP - 225
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
SN - 0924-2708
IS - 4
ER -
ID: 250386963