Association Between Genetic Polymorphisms in the Serotonergic System and Comorbid Personality Disorders Among Patients with First-Episode Depression
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Association Between Genetic Polymorphisms in the Serotonergic System and Comorbid Personality Disorders Among Patients with First-Episode Depression. / Bukh, Jens D; Bock, Camilla; Kessing, Lars V.
I: Journal of Personality Disorders, Bind 28, Nr. 3, 06.2014, s. 365-378.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association Between Genetic Polymorphisms in the Serotonergic System and Comorbid Personality Disorders Among Patients with First-Episode Depression
AU - Bukh, Jens D
AU - Bock, Camilla
AU - Kessing, Lars V
PY - 2014/6
Y1 - 2014/6
N2 - Studies on the association between genetic polymorphisms and personality disorders have provided inconsistent results. Using the "enriched sample method," the authors of the present study aimed to assess the association between polymorphisms in the serotonergic transmitter system and comorbid personality disorders in patients recently diagnosed with first-episode depression. A total of 290 participants were systematically recruited via the Danish Psychiatric Central Research Register. Diagnoses of personality disorders were assessed by a SCID-II interview, and polymorphisms in the genes encoding the serotonin transporter, serotonin receptors 1A, 2A, 2C, and tryptophan hydroxylase 1 were genotyped. The authors found a significant effect of the length polymorphism in the serotonin transporter gene (5-HTTLPR) on cluster B personality disorder (mainly borderline disorder), but no influence on cluster C personality disorder, and no associations between other polymorphisms and personality disorders. The study adds evidence to the effect of the serotonin transporter gene specifically on cluster B personality disorders.
AB - Studies on the association between genetic polymorphisms and personality disorders have provided inconsistent results. Using the "enriched sample method," the authors of the present study aimed to assess the association between polymorphisms in the serotonergic transmitter system and comorbid personality disorders in patients recently diagnosed with first-episode depression. A total of 290 participants were systematically recruited via the Danish Psychiatric Central Research Register. Diagnoses of personality disorders were assessed by a SCID-II interview, and polymorphisms in the genes encoding the serotonin transporter, serotonin receptors 1A, 2A, 2C, and tryptophan hydroxylase 1 were genotyped. The authors found a significant effect of the length polymorphism in the serotonin transporter gene (5-HTTLPR) on cluster B personality disorder (mainly borderline disorder), but no influence on cluster C personality disorder, and no associations between other polymorphisms and personality disorders. The study adds evidence to the effect of the serotonin transporter gene specifically on cluster B personality disorders.
KW - Adult
KW - Comorbidity
KW - Denmark
KW - Depression
KW - Depressive Disorder
KW - Female
KW - Genotype
KW - Humans
KW - Male
KW - Middle Aged
KW - Personality Disorders
KW - Polymorphism, Genetic
KW - Registries
KW - Sampling Studies
KW - Serotonin Plasma Membrane Transport Proteins
U2 - 10.1521/pedi_2013_27_123
DO - 10.1521/pedi_2013_27_123
M3 - Journal article
C2 - 24344840
VL - 28
SP - 365
EP - 378
JO - Journal of Personality Disorders
JF - Journal of Personality Disorders
SN - 0885-579X
IS - 3
ER -
ID: 138306904