Association between cobalt allergy and dermatitis caused by leather articles: a questionnaire study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Association between cobalt allergy and dermatitis caused by leather articles : a questionnaire study. / Bregnbak, David; Thyssen, Jacob P; Zachariae, Claus; Menné, Torkil; Johansen, Jeanne D.
I: Contact Dermatitis, Bind 72, Nr. 2, 02.2015, s. 106-114.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Association between cobalt allergy and dermatitis caused by leather articles
T2 - a questionnaire study
AU - Bregnbak, David
AU - Thyssen, Jacob P
AU - Zachariae, Claus
AU - Menné, Torkil
AU - Johansen, Jeanne D
N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015/2
Y1 - 2015/2
N2 - BACKGROUND: Cobalt is a strong skin sensitizer and a prevalent contact allergen. Recent studies have recognized exposure to leather articles as a potential cause of cobalt allergy.OBJECTIVES: To examine the association between contact allergy to cobalt and a history of dermatitis resulting from exposure to leather.METHODS: A questionnaire case-control study was performed: the case group consisted of 183 dermatitis patients with a positive patch test reaction to cobalt chloride and a negative patch test reaction to potassium dichromate; the control group consisted of 621 dermatitis patients who did not react to either cobalt or chromium in patch testing. Comparisons were made by use of a χ(2) -test, Fisher's exact, and the Mann-Whitney test. Logistic regression analyses were used to test for associations while taking confounding factors into consideration.RESULTS: Leather was observed as the most frequent exposure source causing dermatitis in the case group. Although the case group significantly more often reported non-occupational dermatitis caused by leather exposure (p < 0.001), no association was found between cobalt allergy and dermatitis caused by work-related exposure to leather.CONCLUSIONS: Our study suggests a positive association between cobalt allergy and a history of dermatitis caused by non-occupational exposure to leather articles.
AB - BACKGROUND: Cobalt is a strong skin sensitizer and a prevalent contact allergen. Recent studies have recognized exposure to leather articles as a potential cause of cobalt allergy.OBJECTIVES: To examine the association between contact allergy to cobalt and a history of dermatitis resulting from exposure to leather.METHODS: A questionnaire case-control study was performed: the case group consisted of 183 dermatitis patients with a positive patch test reaction to cobalt chloride and a negative patch test reaction to potassium dichromate; the control group consisted of 621 dermatitis patients who did not react to either cobalt or chromium in patch testing. Comparisons were made by use of a χ(2) -test, Fisher's exact, and the Mann-Whitney test. Logistic regression analyses were used to test for associations while taking confounding factors into consideration.RESULTS: Leather was observed as the most frequent exposure source causing dermatitis in the case group. Although the case group significantly more often reported non-occupational dermatitis caused by leather exposure (p < 0.001), no association was found between cobalt allergy and dermatitis caused by work-related exposure to leather.CONCLUSIONS: Our study suggests a positive association between cobalt allergy and a history of dermatitis caused by non-occupational exposure to leather articles.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Allergens
KW - Case-Control Studies
KW - Cobalt
KW - Cross-Sectional Studies
KW - Dermatitis, Allergic Contact
KW - Dermatitis, Occupational
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Patch Tests
KW - Quality of Life
KW - Severity of Illness Index
KW - Surveys and Questionnaires
KW - Tanning
KW - Young Adult
U2 - 10.1111/cod.12319
DO - 10.1111/cod.12319
M3 - Journal article
C2 - 25407465
VL - 72
SP - 106
EP - 114
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 2
ER -
ID: 156084899