Standard
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies. / Murabito, Joanne M; White, Charles C; Kavousi, Maryam; Sun, Hong Yan; Feitosa, Mary F; Nambi, Vijay; Lamina, Claudia; Schillert, Arne; Coassin, Stefan; Bis, Joshua C; Broer, Linda; Crawford, Dana C; Franceschini, Nora; Frikke-Schmidt, Ruth; Haun, Margot; Holewijn, Suzanne; Huffman, Jennifer E; Hwang, Shih-Jen; Kiechl, Stefan; Kollerits, Barbara; Montasser, May E; Nolte, Ilja M; Rudock, Megan E; Senft, Andrea; Teumer, Alexander; van der Harst, Pim; Vitart, Veronique; Waite, Lindsay L; Wood, Andrew R; Wassel, Christina L; Absher, Devin M; Allison, Matthew A; Amin, Najaf; Arnold, Alice; Asselbergs, Folkert W; Aulchenko, Yurii; Bandinelli, Stefania; Barbalic, Maja; Boban, Mladen; Brown-Gentry, Kristin; Couper, David J; Criqui, Michael H; Dehghan, Abbas; den Heijer, Martin; Dieplinger, Benjamin; Ding, Jingzhong; Dörr, Marcus; Espinola-Klein, Christine; Felix, Stephan B; Ferrucci, Luigi; Folsom, Aaron R; Fraedrich, Gustav; Gibson, Quince; Goodloe, Robert; Gunjaca, Grgo; Haltmayer, Meinhard; Heiss, Gerardo; Hofman, Albert; Kieback, Arne; Kiemeney, Lambertus A; Kolcic, Ivana; Kullo, Iftikhar J; Kritchevsky, Stephen B; Lackner, Karl J; Li, Xiaohui; Lieb, Wolfgang; Lohman, Kurt; Meisinger, Christa; Melzer, David; Mohler, Emile R; Mudnic, Ivana; Mueller, Thomas; Navis, Gerjan; Oberhollenzer, Friedrich; Olin, Jeffrey W; O'Connell, Jeff; O'Donnell, Christopher J; Palmas, Walter; Penninx, Brenda W; Petersmann, Astrid; Polasek, Ozren; Psaty, Bruce M; Rantner, Barbara; Rice, Ken; Rivadeneira, Fernando; Rotter, Jerome I; Seldenrijk, Adrie; Stadler, Marietta; Summerer, Monika; Tanaka, Toshiko; Tybjærg-Hansen, Anne; Uitterlinden, Andre G; van Gilst, Wiek H; Vermeulen, Sita H; Wild, Sarah H; Wild, Philipp S; Willeit, Johann; Zeller, Tanja; Zemunik, Tatijana; Zgaga, Lina; Assimes, Themistocles L; Blankenberg, Stefan; Boerwinkle, Eric; Campbell, Harry; Cooke, John P; de Graaf, Jaqueline; Herrington, David; Kardia, Sharon L R; Mitchell, Braxton D; Murray, Anna; Münzel, Thomas; Newman, Anne; Oostra, Ben A; Rudan, Igor; Shuldiner, Alan R; Snieder, Harold; van Duijn, Cornelia M; Völker, Uwe; Wright, Alan F; Wichmann, H-Erich; Wilson, James; Witteman, Jacqueline C M; Liu, Yongmei; Hayward, Caroline; Borecki, Ingrid B; Ziegler, Andreas; North, Kari E; Cupples, L Adrienne; Kronenberg, Florian.
I:
Circulation: Cardiovascular Genetics, Bind 5, 2012, s. 100-112.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Murabito, JM, White, CC, Kavousi, M, Sun, HY, Feitosa, MF, Nambi, V, Lamina, C, Schillert, A, Coassin, S, Bis, JC, Broer, L, Crawford, DC, Franceschini, N, Frikke-Schmidt, R, Haun, M, Holewijn, S, Huffman, JE, Hwang, S-J, Kiechl, S, Kollerits, B, Montasser, ME, Nolte, IM, Rudock, ME, Senft, A, Teumer, A, van der Harst, P, Vitart, V, Waite, LL, Wood, AR, Wassel, CL, Absher, DM, Allison, MA, Amin, N, Arnold, A, Asselbergs, FW, Aulchenko, Y, Bandinelli, S, Barbalic, M, Boban, M, Brown-Gentry, K, Couper, DJ, Criqui, MH, Dehghan, A, den Heijer, M, Dieplinger, B, Ding, J, Dörr, M, Espinola-Klein, C, Felix, SB, Ferrucci, L, Folsom, AR, Fraedrich, G, Gibson, Q, Goodloe, R, Gunjaca, G, Haltmayer, M, Heiss, G, Hofman, A, Kieback, A, Kiemeney, LA, Kolcic, I, Kullo, IJ, Kritchevsky, SB, Lackner, KJ, Li, X, Lieb, W, Lohman, K, Meisinger, C, Melzer, D, Mohler, ER, Mudnic, I, Mueller, T, Navis, G, Oberhollenzer, F, Olin, JW, O'Connell, J, O'Donnell, CJ, Palmas, W, Penninx, BW, Petersmann, A, Polasek, O, Psaty, BM, Rantner, B, Rice, K, Rivadeneira, F, Rotter, JI, Seldenrijk, A, Stadler, M, Summerer, M, Tanaka, T
, Tybjærg-Hansen, A, Uitterlinden, AG, van Gilst, WH, Vermeulen, SH, Wild, SH, Wild, PS, Willeit, J, Zeller, T, Zemunik, T, Zgaga, L, Assimes, TL, Blankenberg, S, Boerwinkle, E, Campbell, H, Cooke, JP, de Graaf, J, Herrington, D, Kardia, SLR, Mitchell, BD, Murray, A, Münzel, T, Newman, A, Oostra, BA, Rudan, I, Shuldiner, AR, Snieder, H, van Duijn, CM, Völker, U, Wright, AF, Wichmann, H-E, Wilson, J, Witteman, JCM, Liu, Y, Hayward, C, Borecki, IB, Ziegler, A, North, KE, Cupples, LA & Kronenberg, F 2012, '
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies',
Circulation: Cardiovascular Genetics, bind 5, s. 100-112.
https://doi.org/10.1161/CIRCGENETICS.111.961292APA
Murabito, J. M., White, C. C., Kavousi, M., Sun, H. Y., Feitosa, M. F., Nambi, V., Lamina, C., Schillert, A., Coassin, S., Bis, J. C., Broer, L., Crawford, D. C., Franceschini, N., Frikke-Schmidt, R., Haun, M., Holewijn, S., Huffman, J. E., Hwang, S-J., Kiechl, S., ... Kronenberg, F. (2012).
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies.
Circulation: Cardiovascular Genetics,
5, 100-112.
https://doi.org/10.1161/CIRCGENETICS.111.961292Vancouver
Murabito JM, White CC, Kavousi M, Sun HY, Feitosa MF, Nambi V o.a.
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies.
Circulation: Cardiovascular Genetics. 2012;5:100-112.
https://doi.org/10.1161/CIRCGENETICS.111.961292Author
Murabito, Joanne M ; White, Charles C ; Kavousi, Maryam ; Sun, Hong Yan ; Feitosa, Mary F ; Nambi, Vijay ; Lamina, Claudia ; Schillert, Arne ; Coassin, Stefan ; Bis, Joshua C ; Broer, Linda ; Crawford, Dana C ; Franceschini, Nora ; Frikke-Schmidt, Ruth ; Haun, Margot ; Holewijn, Suzanne ; Huffman, Jennifer E ; Hwang, Shih-Jen ; Kiechl, Stefan ; Kollerits, Barbara ; Montasser, May E ; Nolte, Ilja M ; Rudock, Megan E ; Senft, Andrea ; Teumer, Alexander ; van der Harst, Pim ; Vitart, Veronique ; Waite, Lindsay L ; Wood, Andrew R ; Wassel, Christina L ; Absher, Devin M ; Allison, Matthew A ; Amin, Najaf ; Arnold, Alice ; Asselbergs, Folkert W ; Aulchenko, Yurii ; Bandinelli, Stefania ; Barbalic, Maja ; Boban, Mladen ; Brown-Gentry, Kristin ; Couper, David J ; Criqui, Michael H ; Dehghan, Abbas ; den Heijer, Martin ; Dieplinger, Benjamin ; Ding, Jingzhong ; Dörr, Marcus ; Espinola-Klein, Christine ; Felix, Stephan B ; Ferrucci, Luigi ; Folsom, Aaron R ; Fraedrich, Gustav ; Gibson, Quince ; Goodloe, Robert ; Gunjaca, Grgo ; Haltmayer, Meinhard ; Heiss, Gerardo ; Hofman, Albert ; Kieback, Arne ; Kiemeney, Lambertus A ; Kolcic, Ivana ; Kullo, Iftikhar J ; Kritchevsky, Stephen B ; Lackner, Karl J ; Li, Xiaohui ; Lieb, Wolfgang ; Lohman, Kurt ; Meisinger, Christa ; Melzer, David ; Mohler, Emile R ; Mudnic, Ivana ; Mueller, Thomas ; Navis, Gerjan ; Oberhollenzer, Friedrich ; Olin, Jeffrey W ; O'Connell, Jeff ; O'Donnell, Christopher J ; Palmas, Walter ; Penninx, Brenda W ; Petersmann, Astrid ; Polasek, Ozren ; Psaty, Bruce M ; Rantner, Barbara ; Rice, Ken ; Rivadeneira, Fernando ; Rotter, Jerome I ; Seldenrijk, Adrie ; Stadler, Marietta ; Summerer, Monika ; Tanaka, Toshiko ; Tybjærg-Hansen, Anne ; Uitterlinden, Andre G ; van Gilst, Wiek H ; Vermeulen, Sita H ; Wild, Sarah H ; Wild, Philipp S ; Willeit, Johann ; Zeller, Tanja ; Zemunik, Tatijana ; Zgaga, Lina ; Assimes, Themistocles L ; Blankenberg, Stefan ; Boerwinkle, Eric ; Campbell, Harry ; Cooke, John P ; de Graaf, Jaqueline ; Herrington, David ; Kardia, Sharon L R ; Mitchell, Braxton D ; Murray, Anna ; Münzel, Thomas ; Newman, Anne ; Oostra, Ben A ; Rudan, Igor ; Shuldiner, Alan R ; Snieder, Harold ; van Duijn, Cornelia M ; Völker, Uwe ; Wright, Alan F ; Wichmann, H-Erich ; Wilson, James ; Witteman, Jacqueline C M ; Liu, Yongmei ; Hayward, Caroline ; Borecki, Ingrid B ; Ziegler, Andreas ; North, Kari E ; Cupples, L Adrienne ; Kronenberg, Florian. / Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies. I: Circulation: Cardiovascular Genetics. 2012 ; Bind 5. s. 100-112.
Bibtex
@article{4ad49d1046dc414392e45b9f76cf667f,
title = "Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies",
abstract = "BACKGROUND: -Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. METHODS AND RESULTS: -Continuous ABI and PAD (ABI=0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ~2.5 million SNPs in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed-effects inverse variance weighted meta-analyses. There were a total of 41,692 participants of European ancestry (~60% women, mean ABI 1.02 to 1.19), including 3,409 participants with PAD and with GWAS data available. In the discovery meta-analysis, rs10757269 on chromosome 9 near CDKN2B had the strongest association with ABI ({\ss}= -0.006, p=2.46x10(-8)). We sought replication of the 6 strongest SNP associations in 5 population-based studies and 3 clinical samples (n=16,717). The association for rs10757269 strengthened in the combined discovery and replication analysis (p=2.65x10(-9)). No other SNP associations for ABI or PAD achieved genome-wide significance. However, two previously reported candidate genes for PAD and one SNP associated with coronary artery disease (CAD) were associated with ABI: DAB21P (rs13290547, p=3.6x10(-5)); CYBA (rs3794624, p=6.3x10(-5)); and rs1122608 (LDLR, p=0.0026). CONCLUSIONS: -GWAS in more than 40,000 individuals identified one genome-wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for CAD are associated with ABI.",
author = "Murabito, {Joanne M} and White, {Charles C} and Maryam Kavousi and Sun, {Hong Yan} and Feitosa, {Mary F} and Vijay Nambi and Claudia Lamina and Arne Schillert and Stefan Coassin and Bis, {Joshua C} and Linda Broer and Crawford, {Dana C} and Nora Franceschini and Ruth Frikke-Schmidt and Margot Haun and Suzanne Holewijn and Huffman, {Jennifer E} and Shih-Jen Hwang and Stefan Kiechl and Barbara Kollerits and Montasser, {May E} and Nolte, {Ilja M} and Rudock, {Megan E} and Andrea Senft and Alexander Teumer and {van der Harst}, Pim and Veronique Vitart and Waite, {Lindsay L} and Wood, {Andrew R} and Wassel, {Christina L} and Absher, {Devin M} and Allison, {Matthew A} and Najaf Amin and Alice Arnold and Asselbergs, {Folkert W} and Yurii Aulchenko and Stefania Bandinelli and Maja Barbalic and Mladen Boban and Kristin Brown-Gentry and Couper, {David J} and Criqui, {Michael H} and Abbas Dehghan and {den Heijer}, Martin and Benjamin Dieplinger and Jingzhong Ding and Marcus D{\"o}rr and Christine Espinola-Klein and Felix, {Stephan B} and Luigi Ferrucci and Folsom, {Aaron R} and Gustav Fraedrich and Quince Gibson and Robert Goodloe and Grgo Gunjaca and Meinhard Haltmayer and Gerardo Heiss and Albert Hofman and Arne Kieback and Kiemeney, {Lambertus A} and Ivana Kolcic and Kullo, {Iftikhar J} and Kritchevsky, {Stephen B} and Lackner, {Karl J} and Xiaohui Li and Wolfgang Lieb and Kurt Lohman and Christa Meisinger and David Melzer and Mohler, {Emile R} and Ivana Mudnic and Thomas Mueller and Gerjan Navis and Friedrich Oberhollenzer and Olin, {Jeffrey W} and Jeff O'Connell and O'Donnell, {Christopher J} and Walter Palmas and Penninx, {Brenda W} and Astrid Petersmann and Ozren Polasek and Psaty, {Bruce M} and Barbara Rantner and Ken Rice and Fernando Rivadeneira and Rotter, {Jerome I} and Adrie Seldenrijk and Marietta Stadler and Monika Summerer and Toshiko Tanaka and Anne Tybj{\ae}rg-Hansen and Uitterlinden, {Andre G} and {van Gilst}, {Wiek H} and Vermeulen, {Sita H} and Wild, {Sarah H} and Wild, {Philipp S} and Johann Willeit and Tanja Zeller and Tatijana Zemunik and Lina Zgaga and Assimes, {Themistocles L} and Stefan Blankenberg and Eric Boerwinkle and Harry Campbell and Cooke, {John P} and {de Graaf}, Jaqueline and David Herrington and Kardia, {Sharon L R} and Mitchell, {Braxton D} and Anna Murray and Thomas M{\"u}nzel and Anne Newman and Oostra, {Ben A} and Igor Rudan and Shuldiner, {Alan R} and Harold Snieder and {van Duijn}, {Cornelia M} and Uwe V{\"o}lker and Wright, {Alan F} and H-Erich Wichmann and James Wilson and Witteman, {Jacqueline C M} and Yongmei Liu and Caroline Hayward and Borecki, {Ingrid B} and Andreas Ziegler and North, {Kari E} and Cupples, {L Adrienne} and Florian Kronenberg",
year = "2012",
doi = "10.1161/CIRCGENETICS.111.961292",
language = "English",
volume = "5",
pages = "100--112",
journal = "Circulation: Cardiovascular Genetics",
issn = "1942-325X",
publisher = "Lippincott Williams & Wilkins",
}
RIS
TY - JOUR
T1 - Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies
AU - Murabito, Joanne M
AU - White, Charles C
AU - Kavousi, Maryam
AU - Sun, Hong Yan
AU - Feitosa, Mary F
AU - Nambi, Vijay
AU - Lamina, Claudia
AU - Schillert, Arne
AU - Coassin, Stefan
AU - Bis, Joshua C
AU - Broer, Linda
AU - Crawford, Dana C
AU - Franceschini, Nora
AU - Frikke-Schmidt, Ruth
AU - Haun, Margot
AU - Holewijn, Suzanne
AU - Huffman, Jennifer E
AU - Hwang, Shih-Jen
AU - Kiechl, Stefan
AU - Kollerits, Barbara
AU - Montasser, May E
AU - Nolte, Ilja M
AU - Rudock, Megan E
AU - Senft, Andrea
AU - Teumer, Alexander
AU - van der Harst, Pim
AU - Vitart, Veronique
AU - Waite, Lindsay L
AU - Wood, Andrew R
AU - Wassel, Christina L
AU - Absher, Devin M
AU - Allison, Matthew A
AU - Amin, Najaf
AU - Arnold, Alice
AU - Asselbergs, Folkert W
AU - Aulchenko, Yurii
AU - Bandinelli, Stefania
AU - Barbalic, Maja
AU - Boban, Mladen
AU - Brown-Gentry, Kristin
AU - Couper, David J
AU - Criqui, Michael H
AU - Dehghan, Abbas
AU - den Heijer, Martin
AU - Dieplinger, Benjamin
AU - Ding, Jingzhong
AU - Dörr, Marcus
AU - Espinola-Klein, Christine
AU - Felix, Stephan B
AU - Ferrucci, Luigi
AU - Folsom, Aaron R
AU - Fraedrich, Gustav
AU - Gibson, Quince
AU - Goodloe, Robert
AU - Gunjaca, Grgo
AU - Haltmayer, Meinhard
AU - Heiss, Gerardo
AU - Hofman, Albert
AU - Kieback, Arne
AU - Kiemeney, Lambertus A
AU - Kolcic, Ivana
AU - Kullo, Iftikhar J
AU - Kritchevsky, Stephen B
AU - Lackner, Karl J
AU - Li, Xiaohui
AU - Lieb, Wolfgang
AU - Lohman, Kurt
AU - Meisinger, Christa
AU - Melzer, David
AU - Mohler, Emile R
AU - Mudnic, Ivana
AU - Mueller, Thomas
AU - Navis, Gerjan
AU - Oberhollenzer, Friedrich
AU - Olin, Jeffrey W
AU - O'Connell, Jeff
AU - O'Donnell, Christopher J
AU - Palmas, Walter
AU - Penninx, Brenda W
AU - Petersmann, Astrid
AU - Polasek, Ozren
AU - Psaty, Bruce M
AU - Rantner, Barbara
AU - Rice, Ken
AU - Rivadeneira, Fernando
AU - Rotter, Jerome I
AU - Seldenrijk, Adrie
AU - Stadler, Marietta
AU - Summerer, Monika
AU - Tanaka, Toshiko
AU - Tybjærg-Hansen, Anne
AU - Uitterlinden, Andre G
AU - van Gilst, Wiek H
AU - Vermeulen, Sita H
AU - Wild, Sarah H
AU - Wild, Philipp S
AU - Willeit, Johann
AU - Zeller, Tanja
AU - Zemunik, Tatijana
AU - Zgaga, Lina
AU - Assimes, Themistocles L
AU - Blankenberg, Stefan
AU - Boerwinkle, Eric
AU - Campbell, Harry
AU - Cooke, John P
AU - de Graaf, Jaqueline
AU - Herrington, David
AU - Kardia, Sharon L R
AU - Mitchell, Braxton D
AU - Murray, Anna
AU - Münzel, Thomas
AU - Newman, Anne
AU - Oostra, Ben A
AU - Rudan, Igor
AU - Shuldiner, Alan R
AU - Snieder, Harold
AU - van Duijn, Cornelia M
AU - Völker, Uwe
AU - Wright, Alan F
AU - Wichmann, H-Erich
AU - Wilson, James
AU - Witteman, Jacqueline C M
AU - Liu, Yongmei
AU - Hayward, Caroline
AU - Borecki, Ingrid B
AU - Ziegler, Andreas
AU - North, Kari E
AU - Cupples, L Adrienne
AU - Kronenberg, Florian
PY - 2012
Y1 - 2012
N2 - BACKGROUND: -Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. METHODS AND RESULTS: -Continuous ABI and PAD (ABI=0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ~2.5 million SNPs in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed-effects inverse variance weighted meta-analyses. There were a total of 41,692 participants of European ancestry (~60% women, mean ABI 1.02 to 1.19), including 3,409 participants with PAD and with GWAS data available. In the discovery meta-analysis, rs10757269 on chromosome 9 near CDKN2B had the strongest association with ABI (ß= -0.006, p=2.46x10(-8)). We sought replication of the 6 strongest SNP associations in 5 population-based studies and 3 clinical samples (n=16,717). The association for rs10757269 strengthened in the combined discovery and replication analysis (p=2.65x10(-9)). No other SNP associations for ABI or PAD achieved genome-wide significance. However, two previously reported candidate genes for PAD and one SNP associated with coronary artery disease (CAD) were associated with ABI: DAB21P (rs13290547, p=3.6x10(-5)); CYBA (rs3794624, p=6.3x10(-5)); and rs1122608 (LDLR, p=0.0026). CONCLUSIONS: -GWAS in more than 40,000 individuals identified one genome-wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for CAD are associated with ABI.
AB - BACKGROUND: -Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. METHODS AND RESULTS: -Continuous ABI and PAD (ABI=0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ~2.5 million SNPs in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed-effects inverse variance weighted meta-analyses. There were a total of 41,692 participants of European ancestry (~60% women, mean ABI 1.02 to 1.19), including 3,409 participants with PAD and with GWAS data available. In the discovery meta-analysis, rs10757269 on chromosome 9 near CDKN2B had the strongest association with ABI (ß= -0.006, p=2.46x10(-8)). We sought replication of the 6 strongest SNP associations in 5 population-based studies and 3 clinical samples (n=16,717). The association for rs10757269 strengthened in the combined discovery and replication analysis (p=2.65x10(-9)). No other SNP associations for ABI or PAD achieved genome-wide significance. However, two previously reported candidate genes for PAD and one SNP associated with coronary artery disease (CAD) were associated with ABI: DAB21P (rs13290547, p=3.6x10(-5)); CYBA (rs3794624, p=6.3x10(-5)); and rs1122608 (LDLR, p=0.0026). CONCLUSIONS: -GWAS in more than 40,000 individuals identified one genome-wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for CAD are associated with ABI.
U2 - 10.1161/CIRCGENETICS.111.961292
DO - 10.1161/CIRCGENETICS.111.961292
M3 - Journal article
C2 - 22199011
VL - 5
SP - 100
EP - 112
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
SN - 1942-325X
ER -
