Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples
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Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. / Tesli, Martin; Koefoed, Pernille; Athanasiu, Lavinia; Mattingsdal, Morten; Gustafsson, Omar; Agartz, Ingrid; Rimol, Lars M; Brown, Andrew; Wirgenes, Katrine V; Smorr, Lisa-Lena; Kähler, Anna K; Werge, Thomas; Mors, Ole; Mellerup, Erling; Jönsson, Erik G; Melle, Ingrid; Morken, Gunnar; Djurovic, Srdjan; Andreassen, Ole A.
I: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Bind 156, Nr. 8, 01.12.2011, s. 969-74.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples
AU - Tesli, Martin
AU - Koefoed, Pernille
AU - Athanasiu, Lavinia
AU - Mattingsdal, Morten
AU - Gustafsson, Omar
AU - Agartz, Ingrid
AU - Rimol, Lars M
AU - Brown, Andrew
AU - Wirgenes, Katrine V
AU - Smorr, Lisa-Lena
AU - Kähler, Anna K
AU - Werge, Thomas
AU - Mors, Ole
AU - Mellerup, Erling
AU - Jönsson, Erik G
AU - Melle, Ingrid
AU - Morken, Gunnar
AU - Djurovic, Srdjan
AU - Andreassen, Ole A
N1 - Copyright © 2011 Wiley Periodicals, Inc.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N¿=¿854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N¿=¿1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N¿=¿435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N¿=¿1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P¿=¿0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P¿=¿0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N¿=¿1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.
AB - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N¿=¿854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N¿=¿1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N¿=¿435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N¿=¿1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P¿=¿0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P¿=¿0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N¿=¿1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.
U2 - 10.1002/ajmg.b.31244
DO - 10.1002/ajmg.b.31244
M3 - Journal article
C2 - 21972176
VL - 156
SP - 969
EP - 974
JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 8
ER -
ID: 35128489