Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.

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Standard

Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. / Jacobsen, Lars C; Theilgaard-Mönch, Kim; Christensen, Erik I; Borregaard, Niels.

I: Blood, Bind 109, Nr. 7, 2007, s. 3084-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jacobsen, LC, Theilgaard-Mönch, K, Christensen, EI & Borregaard, N 2007, 'Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.', Blood, bind 109, nr. 7, s. 3084-7. https://doi.org/10.1182/blood-2006-06-032599

APA

Jacobsen, L. C., Theilgaard-Mönch, K., Christensen, E. I., & Borregaard, N. (2007). Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Blood, 109(7), 3084-7. https://doi.org/10.1182/blood-2006-06-032599

Vancouver

Jacobsen LC, Theilgaard-Mönch K, Christensen EI, Borregaard N. Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Blood. 2007;109(7):3084-7. https://doi.org/10.1182/blood-2006-06-032599

Author

Jacobsen, Lars C ; Theilgaard-Mönch, Kim ; Christensen, Erik I ; Borregaard, Niels. / Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. I: Blood. 2007 ; Bind 109, Nr. 7. s. 3084-7.

Bibtex

@article{9f8a726058ad11dd8d9f000ea68e967b,
title = "Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.",
abstract = "Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS). The decreased production of nitric oxide (NO) by NOS and the production of ornithine by ARG1 affect immune responses and tissue regeneration at sites of infection, respectively. We here demonstrate that ARG1 is synthesized in myelocytes/metamyelocytes and is stored in gelatinase granules. In accordance with this, activated neutrophils coreleased ARG1 and gelatinase to the extracellular environment on stimulation with phorbol-12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP), or tumor necrosis factor alpha (TNF-alpha). Overall, these findings define ARG1 as a genuine gelatinase granule protein and support a model in which activated neutrophils release ARG1 at sites of infection to modulate immune responses and promote tissue regeneration.",
author = "Jacobsen, {Lars C} and Kim Theilgaard-M{\"o}nch and Christensen, {Erik I} and Niels Borregaard",
note = "Keywords: Arginase; Cytoplasmic Granules; Exocytosis; Gelatinases; Granulocyte Precursor Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha",
year = "2007",
doi = "10.1182/blood-2006-06-032599",
language = "English",
volume = "109",
pages = "3084--7",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "7",

}

RIS

TY - JOUR

T1 - Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.

AU - Jacobsen, Lars C

AU - Theilgaard-Mönch, Kim

AU - Christensen, Erik I

AU - Borregaard, Niels

N1 - Keywords: Arginase; Cytoplasmic Granules; Exocytosis; Gelatinases; Granulocyte Precursor Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

PY - 2007

Y1 - 2007

N2 - Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS). The decreased production of nitric oxide (NO) by NOS and the production of ornithine by ARG1 affect immune responses and tissue regeneration at sites of infection, respectively. We here demonstrate that ARG1 is synthesized in myelocytes/metamyelocytes and is stored in gelatinase granules. In accordance with this, activated neutrophils coreleased ARG1 and gelatinase to the extracellular environment on stimulation with phorbol-12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP), or tumor necrosis factor alpha (TNF-alpha). Overall, these findings define ARG1 as a genuine gelatinase granule protein and support a model in which activated neutrophils release ARG1 at sites of infection to modulate immune responses and promote tissue regeneration.

AB - Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS). The decreased production of nitric oxide (NO) by NOS and the production of ornithine by ARG1 affect immune responses and tissue regeneration at sites of infection, respectively. We here demonstrate that ARG1 is synthesized in myelocytes/metamyelocytes and is stored in gelatinase granules. In accordance with this, activated neutrophils coreleased ARG1 and gelatinase to the extracellular environment on stimulation with phorbol-12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP), or tumor necrosis factor alpha (TNF-alpha). Overall, these findings define ARG1 as a genuine gelatinase granule protein and support a model in which activated neutrophils release ARG1 at sites of infection to modulate immune responses and promote tissue regeneration.

U2 - 10.1182/blood-2006-06-032599

DO - 10.1182/blood-2006-06-032599

M3 - Journal article

C2 - 17119118

VL - 109

SP - 3084

EP - 3087

JO - Blood

JF - Blood

SN - 0006-4971

IS - 7

ER -

ID: 5142818