Apoliprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate
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Apoliprotein E and multiple sclerosis : impact of the epsilon-4 allele on susceptibility, clinical type and progression rate. / Høgh, P; Oturai, A; Schreiber, K; Blinkenberg, M; Jørgensen, O S; Ryder, L; Paulson, O B; Sørensen, P S; Knudsen, G M.
I: Multiple Sclerosis Journal, Bind 6, Nr. 4, 08.2000, s. 226-30.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Apoliprotein E and multiple sclerosis
T2 - impact of the epsilon-4 allele on susceptibility, clinical type and progression rate
AU - Høgh, P
AU - Oturai, A
AU - Schreiber, K
AU - Blinkenberg, M
AU - Jørgensen, O S
AU - Ryder, L
AU - Paulson, O B
AU - Sørensen, P S
AU - Knudsen, G M
PY - 2000/8
Y1 - 2000/8
N2 - The purpose of this study was to investigate the relation between APOE genotype and Multiple Sclerosis (MS) in a genetically homogeneous population. We examined 240 patients consulting the MS-clinic during a period of 3 years (1996 - 1999). The mean age of the patients was 41.7 years (range 19 - 80 Y, SD 10.0 Y). As a measure of the progression rate (PR) the last registered Expanded Disability Status Scale (EDSS) score was divided by the time span (years) from disease onset until the latest assessment. The APOE genotype was determined from saliva and/or blood samples using PCR-techniques. The prevalence of different APOE genotypes was compared with the allele-distribution in a population of 361 persons from a Danish cross-sectional population study. The frequency of APOE-epsilon 4/epsilon 4 homozygotes was significantly higher in the MS-group as compared to controls (P<0.05, odds ratio: 2.3), whereas the frequency distribution of other genotypes did not differ significantly. The rate of progression was significantly faster in the APOE-epsilon 4/epsilon 4 homozygotes compared to other genotypes in the MS group (P<0.05). This study suggests that the APOE-epsilon 4/epsilon 4 homozygotes have an increased risk of developing MS. MS patients with the APOE-epsilon 4/epsilon 4 allele may also have an increased rate of disease progression. Multiple Sclerosis (2000) 6 226 - 230
AB - The purpose of this study was to investigate the relation between APOE genotype and Multiple Sclerosis (MS) in a genetically homogeneous population. We examined 240 patients consulting the MS-clinic during a period of 3 years (1996 - 1999). The mean age of the patients was 41.7 years (range 19 - 80 Y, SD 10.0 Y). As a measure of the progression rate (PR) the last registered Expanded Disability Status Scale (EDSS) score was divided by the time span (years) from disease onset until the latest assessment. The APOE genotype was determined from saliva and/or blood samples using PCR-techniques. The prevalence of different APOE genotypes was compared with the allele-distribution in a population of 361 persons from a Danish cross-sectional population study. The frequency of APOE-epsilon 4/epsilon 4 homozygotes was significantly higher in the MS-group as compared to controls (P<0.05, odds ratio: 2.3), whereas the frequency distribution of other genotypes did not differ significantly. The rate of progression was significantly faster in the APOE-epsilon 4/epsilon 4 homozygotes compared to other genotypes in the MS group (P<0.05). This study suggests that the APOE-epsilon 4/epsilon 4 homozygotes have an increased risk of developing MS. MS patients with the APOE-epsilon 4/epsilon 4 allele may also have an increased rate of disease progression. Multiple Sclerosis (2000) 6 226 - 230
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Analysis of Variance
KW - Apolipoprotein E4
KW - Apolipoproteins E/genetics
KW - Cross-Sectional Studies
KW - Disability Evaluation
KW - Disease Progression
KW - Female
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Homozygote
KW - Humans
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis/genetics
KW - Time Factors
U2 - 10.1177/135245850000600403
DO - 10.1177/135245850000600403
M3 - Journal article
C2 - 10962542
VL - 6
SP - 226
EP - 230
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 4
ER -
ID: 260897007