Antimyostatin treatment in health and disease: The story of great expectations and limited success
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In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical studies have shown potential for increasing muscular mass and ameliorating the pathological features of dystrophic muscle by the inhibition of myostatin in various ways. However, hardly any clinical trials have proven to translate the promising results from the animal models into patient popula-tions. We present the background for myostatin regulation, clinical and preclinical results and dis-cuss why translation from animal models to patients is difficult. Based on this, we put the clinical relevance of future antimyostatin treatment into perspective.
Originalsprog | Engelsk |
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Artikelnummer | 533 |
Tidsskrift | Cells |
Vol/bind | 10 |
Udgave nummer | 3 |
Antal sider | 31 |
ISSN | 2073-4409 |
DOI | |
Status | Udgivet - 2021 |
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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