Antimicrobial Peptides in Hidradenitis Suppurativa – A Systematic Review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Antimicrobial Peptides in Hidradenitis Suppurativa – A Systematic Review. / Yao, Y.; Frew, J. W.; Thomsen, S. F.; Ring, Hans Christian.
I: British Journal of Dermatology, Bind 186, Nr. 2, 2022, s. 236-244.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Antimicrobial Peptides in Hidradenitis Suppurativa – A Systematic Review
AU - Yao, Y.
AU - Frew, J. W.
AU - Thomsen, S. F.
AU - Ring, Hans Christian
PY - 2022
Y1 - 2022
N2 - Hidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additionally, the reference lists of the included articles were screened and manually searched for relevant studies. The final literature sample is comprised of 18 retrospective and prospective studies (non-review and non-commentary) published between 2009 and 2020. This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies may vary, the studies included indicate a consistent overexpression of hBD-2, S100A7, S100A8, and S100A9 at both mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional – and non-lesional HS skin.
AB - Hidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additionally, the reference lists of the included articles were screened and manually searched for relevant studies. The final literature sample is comprised of 18 retrospective and prospective studies (non-review and non-commentary) published between 2009 and 2020. This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies may vary, the studies included indicate a consistent overexpression of hBD-2, S100A7, S100A8, and S100A9 at both mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional – and non-lesional HS skin.
U2 - 10.1111/bjd.20750
DO - 10.1111/bjd.20750
M3 - Review
C2 - 34498267
VL - 186
SP - 236
EP - 244
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -
ID: 279715959