Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. / Jensen, Michael Ladegaard; Thymann, Thomas; Cilieborg, Malene Skovsted; Jensen, Mikkel Lykke; Mølbak, Lars; Jensen, Bent B; Schmidt, Mette; Kelly, Denise; Mulder, Imke; Burrin, Douglas G; Sangild, Per Torp.
I: American Journal of Physiology: Gastrointestinal and Liver Physiology, Bind 306, Nr. 1, 2014, s. G59-G71.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets
AU - Jensen, Michael Ladegaard
AU - Thymann, Thomas
AU - Cilieborg, Malene Skovsted
AU - Jensen, Mikkel Lykke
AU - Mølbak, Lars
AU - Jensen, Bent B
AU - Schmidt, Mette
AU - Kelly, Denise
AU - Mulder, Imke
AU - Burrin, Douglas G
AU - Sangild, Per Torp
N1 - CURIS 2014 NEXS 003
PY - 2014
Y1 - 2014
N2 - Preterm birth, bacterial colonization and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotics treatment improves NEC resistance and intestinal structure, function and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula. Immediately after birth they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin and metronidazole, ANTI, n=11) or saline in the control group (CON, n=13), given twice daily. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by d 5 (0/11 vs. 11/13, P
AB - Preterm birth, bacterial colonization and formula feeding predispose to necrotizing enterocolitis (NEC). Antibiotics are commonly administered to prevent sepsis in preterm infants, but it is not known whether this affects intestinal immunity and NEC resistance. We hypothesized that broad-spectrum antibiotics treatment improves NEC resistance and intestinal structure, function and immunity in neonates. Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula. Immediately after birth they were assigned to receive either antibiotics (oral and parenteral doses of gentamycin, ampicillin and metronidazole, ANTI, n=11) or saline in the control group (CON, n=13), given twice daily. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. None of the ANTI but 85% of the CON pigs developed NEC lesions by d 5 (0/11 vs. 11/13, P
U2 - 10.1152/ajpgi.00213.2013
DO - 10.1152/ajpgi.00213.2013
M3 - Journal article
C2 - 24157972
VL - 306
SP - G59-G71
JO - American Journal of Physiology: Gastrointestinal and Liver Physiology
JF - American Journal of Physiology: Gastrointestinal and Liver Physiology
SN - 0193-1857
IS - 1
ER -
ID: 91314576