TY - JOUR

T1 - Antenatal corticosteroids affecting enteral feeding and growth of preterm infants

T2 - A retrospective cohort study

AU - Luo, Ping

AU - Liu, Xudong

AU - Ma, Liya

AU - Chen, You

AU - Zhang, Kun

AU - Zhou, Ping

AU - Jiang, Yan Nan

AU - Jiang, Ping Ping

N1 - Publisher Copyright: © 2021 American Society for Parenteral and Enteral Nutrition

PY - 2022

Y1 - 2022

N2 - Background: Treatment of antenatal corticosteroids (ACSs) to women at risk of preterm labor can decrease neonatal mortality and morbidity. However, effect of ACS exposure on enteral feeding and body growth of preterm infants remains elusive. Methods: This retrospective study collected information of eligible singleton infants born between 22+0 and 36+6 weeks’ gestation from 2017 to 2019. Logistic regression and multivariate linear regression were adopted to examine the associations of the ACS exposure with various outcomes of enteral feeding and growth considering potential confounders. Stratified analysis was performed based on gestational age (GA) (<34 vs ≥34 weeks). Results: Of the 1694 preterm infants included, 1222 (72.1%) were exposed to ACSs. Infants with ACS exposure had a higher incidence of feeding intolerance (odds ratio 1.51; 95% CI, 1.05 to 2.20; P =.03), slower advancement of enteral feeding (β coefficient −0.86; 95% CI, −1.48 to −0.25; P =.01), and lower delta body-weight z-scores (β coefficient−0.13; 95% CI, −0.18 to −0.08; P <.001). Unlike in infants with GA <34 weeks, ACS exposure was associated with slower advancement of enteral feeding, longer time to regain birth weight, and lower delta body-weight z-scores in the ones with GA ≥34 weeks. Conclusion: ACS exposure is associated with poorer enteral feeding process and body growth in our study population, which is more prominent in late preterm infants. A multicenter prospective study and mechanistic studies using animal models are required.

AB - Background: Treatment of antenatal corticosteroids (ACSs) to women at risk of preterm labor can decrease neonatal mortality and morbidity. However, effect of ACS exposure on enteral feeding and body growth of preterm infants remains elusive. Methods: This retrospective study collected information of eligible singleton infants born between 22+0 and 36+6 weeks’ gestation from 2017 to 2019. Logistic regression and multivariate linear regression were adopted to examine the associations of the ACS exposure with various outcomes of enteral feeding and growth considering potential confounders. Stratified analysis was performed based on gestational age (GA) (<34 vs ≥34 weeks). Results: Of the 1694 preterm infants included, 1222 (72.1%) were exposed to ACSs. Infants with ACS exposure had a higher incidence of feeding intolerance (odds ratio 1.51; 95% CI, 1.05 to 2.20; P =.03), slower advancement of enteral feeding (β coefficient −0.86; 95% CI, −1.48 to −0.25; P =.01), and lower delta body-weight z-scores (β coefficient−0.13; 95% CI, −0.18 to −0.08; P <.001). Unlike in infants with GA <34 weeks, ACS exposure was associated with slower advancement of enteral feeding, longer time to regain birth weight, and lower delta body-weight z-scores in the ones with GA ≥34 weeks. Conclusion: ACS exposure is associated with poorer enteral feeding process and body growth in our study population, which is more prominent in late preterm infants. A multicenter prospective study and mechanistic studies using animal models are required.

KW - antenatal corticosteroids

KW - enteral feeding

KW - growth

KW - preterm infants

U2 - 10.1002/jpen.2215

DO - 10.1002/jpen.2215

M3 - Journal article

C2 - 34190351

AN - SCOPUS:85111812802

VL - 46

SP - 572

EP - 582

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

IS - 3

ER -