Antenatal corticosteroids affecting enteral feeding and growth of preterm infants: A retrospective cohort study
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Antenatal corticosteroids affecting enteral feeding and growth of preterm infants : A retrospective cohort study. / Luo, Ping; Liu, Xudong; Ma, Liya; Chen, You; Zhang, Kun; Zhou, Ping; Jiang, Yan Nan; Jiang, Ping Ping.
I: Journal of Parenteral and Enteral Nutrition, Bind 46, Nr. 3, 2022, s. 572-582.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Antenatal corticosteroids affecting enteral feeding and growth of preterm infants
T2 - A retrospective cohort study
AU - Luo, Ping
AU - Liu, Xudong
AU - Ma, Liya
AU - Chen, You
AU - Zhang, Kun
AU - Zhou, Ping
AU - Jiang, Yan Nan
AU - Jiang, Ping Ping
N1 - Publisher Copyright: © 2021 American Society for Parenteral and Enteral Nutrition
PY - 2022
Y1 - 2022
N2 - Background: Treatment of antenatal corticosteroids (ACSs) to women at risk of preterm labor can decrease neonatal mortality and morbidity. However, effect of ACS exposure on enteral feeding and body growth of preterm infants remains elusive. Methods: This retrospective study collected information of eligible singleton infants born between 22+0 and 36+6 weeks’ gestation from 2017 to 2019. Logistic regression and multivariate linear regression were adopted to examine the associations of the ACS exposure with various outcomes of enteral feeding and growth considering potential confounders. Stratified analysis was performed based on gestational age (GA) (<34 vs ≥34 weeks). Results: Of the 1694 preterm infants included, 1222 (72.1%) were exposed to ACSs. Infants with ACS exposure had a higher incidence of feeding intolerance (odds ratio 1.51; 95% CI, 1.05 to 2.20; P =.03), slower advancement of enteral feeding (β coefficient −0.86; 95% CI, −1.48 to −0.25; P =.01), and lower delta body-weight z-scores (β coefficient−0.13; 95% CI, −0.18 to −0.08; P <.001). Unlike in infants with GA <34 weeks, ACS exposure was associated with slower advancement of enteral feeding, longer time to regain birth weight, and lower delta body-weight z-scores in the ones with GA ≥34 weeks. Conclusion: ACS exposure is associated with poorer enteral feeding process and body growth in our study population, which is more prominent in late preterm infants. A multicenter prospective study and mechanistic studies using animal models are required.
AB - Background: Treatment of antenatal corticosteroids (ACSs) to women at risk of preterm labor can decrease neonatal mortality and morbidity. However, effect of ACS exposure on enteral feeding and body growth of preterm infants remains elusive. Methods: This retrospective study collected information of eligible singleton infants born between 22+0 and 36+6 weeks’ gestation from 2017 to 2019. Logistic regression and multivariate linear regression were adopted to examine the associations of the ACS exposure with various outcomes of enteral feeding and growth considering potential confounders. Stratified analysis was performed based on gestational age (GA) (<34 vs ≥34 weeks). Results: Of the 1694 preterm infants included, 1222 (72.1%) were exposed to ACSs. Infants with ACS exposure had a higher incidence of feeding intolerance (odds ratio 1.51; 95% CI, 1.05 to 2.20; P =.03), slower advancement of enteral feeding (β coefficient −0.86; 95% CI, −1.48 to −0.25; P =.01), and lower delta body-weight z-scores (β coefficient−0.13; 95% CI, −0.18 to −0.08; P <.001). Unlike in infants with GA <34 weeks, ACS exposure was associated with slower advancement of enteral feeding, longer time to regain birth weight, and lower delta body-weight z-scores in the ones with GA ≥34 weeks. Conclusion: ACS exposure is associated with poorer enteral feeding process and body growth in our study population, which is more prominent in late preterm infants. A multicenter prospective study and mechanistic studies using animal models are required.
KW - antenatal corticosteroids
KW - enteral feeding
KW - growth
KW - preterm infants
U2 - 10.1002/jpen.2215
DO - 10.1002/jpen.2215
M3 - Journal article
C2 - 34190351
AN - SCOPUS:85111812802
VL - 46
SP - 572
EP - 582
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
SN - 0148-6071
IS - 3
ER -
ID: 299105553