Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke
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Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke. / Waldemar, G; Vorstrup, S; Andersen, A R; Pedersen, H; Paulson, O B.
I: Journal of Cardiovascular Pharmacology, Bind 14, Nr. 5, 11.1989, s. 722-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke
AU - Waldemar, G
AU - Vorstrup, S
AU - Andersen, A R
AU - Pedersen, H
AU - Paulson, O B
PY - 1989/11
Y1 - 1989/11
N2 - The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.
AB - The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.
KW - Acute Disease
KW - Aged
KW - Aged, 80 and over
KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology
KW - Blood Pressure/drug effects
KW - Captopril/pharmacology
KW - Cerebrovascular Circulation/drug effects
KW - Cerebrovascular Disorders/diagnostic imaging
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Tomography, Emission-Computed
KW - Xenon Radioisotopes
U2 - 10.1097/00005344-198911000-00008
DO - 10.1097/00005344-198911000-00008
M3 - Journal article
C2 - 2481186
VL - 14
SP - 722
EP - 729
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 5
ER -
ID: 275282123