Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus

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Standard

Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus. / Schmidt, J F; Andersen, A R; Paulson, O B; Gjerris, Flemming.

I: Acta Neurochirurgica, Bind 106, Nr. 1-2, 1990, s. 9-12.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schmidt, JF, Andersen, AR, Paulson, OB & Gjerris, F 1990, 'Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus', Acta Neurochirurgica, bind 106, nr. 1-2, s. 9-12. https://doi.org/10.1007/BF01809326

APA

Schmidt, J. F., Andersen, A. R., Paulson, O. B., & Gjerris, F. (1990). Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus. Acta Neurochirurgica, 106(1-2), 9-12. https://doi.org/10.1007/BF01809326

Vancouver

Schmidt JF, Andersen AR, Paulson OB, Gjerris F. Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus. Acta Neurochirurgica. 1990;106(1-2):9-12. https://doi.org/10.1007/BF01809326

Author

Schmidt, J F ; Andersen, A R ; Paulson, O B ; Gjerris, Flemming. / Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus. I: Acta Neurochirurgica. 1990 ; Bind 106, Nr. 1-2. s. 9-12.

Bibtex

@article{9d24579013994010a57ffef89788d7b8,

title = "Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus",

abstract = "Fourteen patients with normal pressure hydrocephalus had the autoregulation of cerebral blood flow (CBF) and intracranial pressure (ICP) investigated. In 8 of the patients the effect of Captopril on ICP and CBF was also investigated. The mean arterial blood pressure (MABP) was 109 mmHg (intra-arterially), and ICP was 11 mmHg (intraventricularly). Changes in global CBF were estimated by the arterio-venous oxygen difference method. The autoregulation of CBF was present in 13 of the patients (p less than 0.01). The lower limit of CBF autoregulation was 86% of the baseline perfusion pressure. One hour after 50 mg of captopril perorally, MABP was reduced 16 mmHg, and ICP and CBF were unchanged. The autoregulation was maintained and the lower limit was decreased 19 mmHg. Thus patients would be expected to benefit from captopril treatment in hypotensive anaesthesia.",

keywords = "Administration, Oral, Adult, Aged, Blood Pressure/drug effects, Captopril/therapeutic use, Cerebrospinal Fluid Pressure/drug effects, Dose-Response Relationship, Drug, Female, Homeostasis/drug effects, Humans, Hydrocephalus, Normal Pressure/drug therapy, Intracranial Pressure/drug effects, Male, Middle Aged",

author = "Schmidt, {J F} and Andersen, {A R} and Paulson, {O B} and Flemming Gjerris",

year = "1990",

doi = "10.1007/BF01809326",

language = "English",

volume = "106",

pages = "9--12",

journal = "Acta Neurochirurgica",

issn = "0001-6268",

publisher = "Springer Wien",

number = "1-2",

}

RIS

TY - JOUR

T1 - Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus

AU - Schmidt, J F

AU - Andersen, A R

AU - Paulson, O B

AU - Gjerris, Flemming

PY - 1990

Y1 - 1990

N2 - Fourteen patients with normal pressure hydrocephalus had the autoregulation of cerebral blood flow (CBF) and intracranial pressure (ICP) investigated. In 8 of the patients the effect of Captopril on ICP and CBF was also investigated. The mean arterial blood pressure (MABP) was 109 mmHg (intra-arterially), and ICP was 11 mmHg (intraventricularly). Changes in global CBF were estimated by the arterio-venous oxygen difference method. The autoregulation of CBF was present in 13 of the patients (p less than 0.01). The lower limit of CBF autoregulation was 86% of the baseline perfusion pressure. One hour after 50 mg of captopril perorally, MABP was reduced 16 mmHg, and ICP and CBF were unchanged. The autoregulation was maintained and the lower limit was decreased 19 mmHg. Thus patients would be expected to benefit from captopril treatment in hypotensive anaesthesia.

AB - Fourteen patients with normal pressure hydrocephalus had the autoregulation of cerebral blood flow (CBF) and intracranial pressure (ICP) investigated. In 8 of the patients the effect of Captopril on ICP and CBF was also investigated. The mean arterial blood pressure (MABP) was 109 mmHg (intra-arterially), and ICP was 11 mmHg (intraventricularly). Changes in global CBF were estimated by the arterio-venous oxygen difference method. The autoregulation of CBF was present in 13 of the patients (p less than 0.01). The lower limit of CBF autoregulation was 86% of the baseline perfusion pressure. One hour after 50 mg of captopril perorally, MABP was reduced 16 mmHg, and ICP and CBF were unchanged. The autoregulation was maintained and the lower limit was decreased 19 mmHg. Thus patients would be expected to benefit from captopril treatment in hypotensive anaesthesia.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Blood Pressure/drug effects

KW - Captopril/therapeutic use

KW - Cerebrospinal Fluid Pressure/drug effects

KW - Dose-Response Relationship, Drug

KW - Female

KW - Homeostasis/drug effects

KW - Humans

KW - Hydrocephalus, Normal Pressure/drug therapy

KW - Intracranial Pressure/drug effects

KW - Male

KW - Middle Aged

U2 - 10.1007/BF01809326

DO - 10.1007/BF01809326

M3 - Journal article

C2 - 2270793

VL - 106

SP - 9

EP - 12

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

IS - 1-2

ER -

ID: 275129429