TY - JOUR

T1 - Anatomical patterns of dermatitis in adult filaggrin mutation carriers

AU - Heede, Nina G

AU - Thyssen, Jacob Pontoppidan

AU - Thuesen, Betina H

AU - Linneberg, Allan René

AU - Johansen, Jeanne Duus

N1 - Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - BACKGROUND: Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population.OBJECTIVE: We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype.METHODS: Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years. Information about dermatitis on the hands; feet; face; axillae; and abdomen, chest, or back was obtained by use of questionnaires. Participants were genotyped for common FLG mutations. A history of AD was defined by the United Kingdom Working Party's diagnostic criteria.RESULTS: The frequency of foot dermatitis in the general population was associated with FLG genotype (P = .014). However, when stratification of FLG genotype and AD was performed, we found that FLG mutations increased the prevalence (odds ratios) of foot dermatitis (odds ratio 10.41; 95% confidence interval 5.27-20.60) and persistent hand dermatitis (odds ratio 17.57; 95% confidence interval 8.60-35.89) only in participants with AD.LIMITATIONS: Potential misclassification and recall bias are study limitations.CONCLUSION: FLG mutations affected the lifetime prevalence of hand and foot dermatitis in participants with a history of AD.

AB - BACKGROUND: Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population.OBJECTIVE: We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype.METHODS: Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years. Information about dermatitis on the hands; feet; face; axillae; and abdomen, chest, or back was obtained by use of questionnaires. Participants were genotyped for common FLG mutations. A history of AD was defined by the United Kingdom Working Party's diagnostic criteria.RESULTS: The frequency of foot dermatitis in the general population was associated with FLG genotype (P = .014). However, when stratification of FLG genotype and AD was performed, we found that FLG mutations increased the prevalence (odds ratios) of foot dermatitis (odds ratio 10.41; 95% confidence interval 5.27-20.60) and persistent hand dermatitis (odds ratio 17.57; 95% confidence interval 8.60-35.89) only in participants with AD.LIMITATIONS: Potential misclassification and recall bias are study limitations.CONCLUSION: FLG mutations affected the lifetime prevalence of hand and foot dermatitis in participants with a history of AD.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Dermatitis, Atopic

KW - Female

KW - Genotype

KW - Humans

KW - Intermediate Filament Proteins

KW - Male

KW - Middle Aged

KW - Mutation

KW - Young Adult

U2 - 10.1016/j.jaad.2015.01.001

DO - 10.1016/j.jaad.2015.01.001

M3 - Journal article

C2 - 25659224

VL - 72

SP - 440

EP - 448

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 3

ER -