Analyzing skin tumor development in mice by the DMBA/TPA model
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Analyzing skin tumor development in mice by the DMBA/TPA model. / Li, Hui; Brakebusch, Cord.
Carcinogen-driven mouse models of oncogenesis. red. / Lorenzo Galluzzi; Aitziber Buqué. Bind 163 Elsevier, 2021. s. 113-121 (Methods in Cell Biology).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
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TY - CHAP
T1 - Analyzing skin tumor development in mice by the DMBA/TPA model
AU - Li, Hui
AU - Brakebusch, Cord
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Mice are the most important animals to model tumor formation and malignant progression in humans. Chemical induction of skin tumors in mice by treatment with DMBA and TPA is a well-studied tumor induction model that is easy to use and directly applicable to genetically modified mice without any mandatory crossing with mice carrying mutations in oncogenes and tumorsuppressors. This article describes the basic protocol for DMBA/TPA induced skin tumor formation and discusses the advantages and limitations of this model, in particular the translatability of results obtained in this system to human cancer patients.
AB - Mice are the most important animals to model tumor formation and malignant progression in humans. Chemical induction of skin tumors in mice by treatment with DMBA and TPA is a well-studied tumor induction model that is easy to use and directly applicable to genetically modified mice without any mandatory crossing with mice carrying mutations in oncogenes and tumorsuppressors. This article describes the basic protocol for DMBA/TPA induced skin tumor formation and discusses the advantages and limitations of this model, in particular the translatability of results obtained in this system to human cancer patients.
U2 - 10.1016/bs.mcb.2020.08.004
DO - 10.1016/bs.mcb.2020.08.004
M3 - Book chapter
C2 - 33785160
VL - 163
T3 - Methods in Cell Biology
SP - 113
EP - 121
BT - Carcinogen-driven mouse models of oncogenesis
A2 - Galluzzi, Lorenzo
A2 - Buqué, Aitziber
PB - Elsevier
ER -
ID: 274873491