An N-glycan on the C2 domain of JAGGED1 is important for Notch activation
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Originalsprog | Engelsk |
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Artikelnummer | eabo3507 |
Tidsskrift | Science Signaling |
Vol/bind | 15 |
Udgave nummer | 755 |
ISSN | 1945-0877 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
We thank A. Davies for assistance with COSMIC variant cloning and purification. We thank K. Kemppainen for technical guidance and insightful comments. We are grateful to R. Kopan and D. Sprinzak for Notch reporter reagents. We thank C. Redfield for critical reading of the manuscript : This research was funded in whole or in part by MRC, a cOAlition S organization. The authors will make the Author Accepted Manuscript (AAM) version available under a CC BY public copyright license. This was supported by MRC grant MR-R009317-1 and MR-V008935-1 awarded to P.A.H., as well as InFLAMES Flagship Programme of the Academy of Finland (decision number 337530; to C.S. and S.S.) and the Academy of Finland (decision numbers 316882, 330411, and 307133; to C.S. and S.S.). A.H.L. was supported by the Carlsberg Foundation, grant CF19-0288. Y.M. was supported by an overseas scholarship from St Catherine’s College, Oxford. W.B.S. and S.A.B. are supported by funding from the UK Research and Innovation (UKRI) Future Leaders Fellowship (grant number MR/V02213X/1). Cellular imaging was performed in Cell Imaging and Cytometry Core, Turku Bioscience, Turku, Finland, supported by Biocenter Finland.
Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved.
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