An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy
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An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. / Brownbill, Paul; Chernyavsky, Igor; Bottalico, Barbara; Desoye, Gernot; Hansson, Stefan; Kenna, Gerry; Knudsen, Lisbeth E.; Markert, Udo R.; Powles-Glover, Nicola; Schneider, Henning; Leach, Lopa.
I: Reproductive Toxicology, Bind 64, 09.2016, s. 191-202.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy
AU - Brownbill, Paul
AU - Chernyavsky, Igor
AU - Bottalico, Barbara
AU - Desoye, Gernot
AU - Hansson, Stefan
AU - Kenna, Gerry
AU - Knudsen, Lisbeth E.
AU - Markert, Udo R.
AU - Powles-Glover, Nicola
AU - Schneider, Henning
AU - Leach, Lopa
N1 - This article belongs to a special issue: 44th Annual Conference of the European Teratology Society.
PY - 2016/9
Y1 - 2016/9
N2 - The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.
AB - The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice.
KW - PlaNet
KW - Human placenta
KW - Reproductive toxicology testing
KW - 3Rs
U2 - 10.1016/j.reprotox.2016.06.006
DO - 10.1016/j.reprotox.2016.06.006
M3 - Journal article
C2 - 27327413
VL - 64
SP - 191
EP - 202
JO - Reproductive Toxicology
JF - Reproductive Toxicology
SN - 0890-6238
ER -
ID: 166323628