TY - JOUR

T1 - An exploratory analysis of clinical and sociodemographic factors in CGRP-induced migraine attacks

T2 - A REFORM study

AU - Al-Khazali, Haidar M.

AU - Ashina, Håkan

AU - Christensen, Rune Häckert

AU - Wiggers, Astrid

AU - Rose, Kathrine

AU - Iljazi, Afrim

AU - Schytz, Henrik W.

AU - Amin, Faisal Mohammad

AU - Ashina, Messoud

N1 - Publisher Copyright: © International Headache Society 2023.

PY - 2023

Y1 - 2023

N2 - Objective: To investigate whether clinical and sociodemographic factors are associated with calcitonin gene-related peptide (CGRP) induced migraine attacks. Methods: A total of 139 participants with migraine received a 20-minute intravenous infusion of CGRP (1.5 µg/min) on a single experiment day. The incidence of CGRP-induced migraine attacks was recorded using a headache diary during the 12-hour observational period post-infusion. Univariable and multivariable regression analyses were conducted to examine potential predictors' relationship with CGRP-induced migraine attacks. Results: CGRP-induced migraine attacks were reported in 110 (79%) of 139 participants. Univariable analysis revealed that participants with cutaneous allodynia had higher odds of developing CGRP-induced migraine attacks, compared with those without allodynia (OR, 2.97, 95% CI, 1.28 to 7.43). The subsequent multivariable analysis confirmed this association (OR, 3.26, 95% CI, 1.32 to 8.69) and also found that participants with migraine with aura had lower odds of developing CGRP-induced migraine attacks (OR, 0.32, 95% CI, 0.12 to 0.84). Conclusion: Our results suggest that cutaneous allodynia and aura play a role in CGRP-induced migraine attacks, while other clinical and sociodemographic factors do not seem to have any noticeable impact. This indicates that the CGRP provocation model is robust, as the CGRP hypersensitivity remained unaffected despite differences among a heterogeneous migraine population. Trial Registration: ClinicalTrials.gov Identifier: NCT04592952.

AB - Objective: To investigate whether clinical and sociodemographic factors are associated with calcitonin gene-related peptide (CGRP) induced migraine attacks. Methods: A total of 139 participants with migraine received a 20-minute intravenous infusion of CGRP (1.5 µg/min) on a single experiment day. The incidence of CGRP-induced migraine attacks was recorded using a headache diary during the 12-hour observational period post-infusion. Univariable and multivariable regression analyses were conducted to examine potential predictors' relationship with CGRP-induced migraine attacks. Results: CGRP-induced migraine attacks were reported in 110 (79%) of 139 participants. Univariable analysis revealed that participants with cutaneous allodynia had higher odds of developing CGRP-induced migraine attacks, compared with those without allodynia (OR, 2.97, 95% CI, 1.28 to 7.43). The subsequent multivariable analysis confirmed this association (OR, 3.26, 95% CI, 1.32 to 8.69) and also found that participants with migraine with aura had lower odds of developing CGRP-induced migraine attacks (OR, 0.32, 95% CI, 0.12 to 0.84). Conclusion: Our results suggest that cutaneous allodynia and aura play a role in CGRP-induced migraine attacks, while other clinical and sociodemographic factors do not seem to have any noticeable impact. This indicates that the CGRP provocation model is robust, as the CGRP hypersensitivity remained unaffected despite differences among a heterogeneous migraine population. Trial Registration: ClinicalTrials.gov Identifier: NCT04592952.

KW - CGRP hypersensitivity

KW - Headache disorders

KW - prediction

U2 - 10.1177/03331024231206375

DO - 10.1177/03331024231206375

M3 - Journal article

C2 - 37815254

AN - SCOPUS:85175587094

VL - 43

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 10

ER -