Alpha proteobacterial ancestry of the [Fe-Fe]-hydrogenases in anaerobic eukaryotes
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Alpha proteobacterial ancestry of the [Fe-Fe]-hydrogenases in anaerobic eukaryotes. / Degli Esposti, Mauro; Cortez, Diego; Lozano, Luis; Rasmussen, Simon; Nielsen, Henrik Bjørn; Martinez Romero, Esperanza.
I: Biology Direct, Bind 11, 30.07.2016, s. 34.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Alpha proteobacterial ancestry of the [Fe-Fe]-hydrogenases in anaerobic eukaryotes
AU - Degli Esposti, Mauro
AU - Cortez, Diego
AU - Lozano, Luis
AU - Rasmussen, Simon
AU - Nielsen, Henrik Bjørn
AU - Martinez Romero, Esperanza
PY - 2016/7/30
Y1 - 2016/7/30
N2 - UNLABELLED: Eukaryogenesis, a major transition in evolution of life, originated from the symbiogenic fusion of an archaea with a metabolically versatile bacterium. By general consensus, the latter organism belonged to α proteobacteria, subsequently evolving into the mitochondrial organelle of our cells. The consensus is based upon genetic and metabolic similarities between mitochondria and aerobic α proteobacteria but fails to explain the origin of several enzymes found in the mitochondria-derived organelles of anaerobic eukaryotes such as Trichomonas and Entamoeba. These enzymes are thought to derive from bacterial lineages other than α proteobacteria, e.g., Clostridium - an obligate anaerobe. [FeFe]-hydrogenase constitues the characteristic enzyme of this anaerobic metabolism and is present in different types also in Entamoeba and other anaerobic eukaryotes. Here we show that α proteobacteria derived from metagenomic studies possess both the cytosolic and organellar type of [FeFe]-hydrogenase, as well as all the proteins required for hydrogenase maturation. These organisms are related to cultivated members of the Rhodospirillales order previously suggested to be close relatives of mitochondrial ancestors. For the first time, our evidence supports an α proteobacterial ancestry for both the anaerobic and the aerobic metabolism of eukaryotes.REVIEWERS: This article was reviewed by William Martin and Nick Lane, both suggested by the Authors.
AB - UNLABELLED: Eukaryogenesis, a major transition in evolution of life, originated from the symbiogenic fusion of an archaea with a metabolically versatile bacterium. By general consensus, the latter organism belonged to α proteobacteria, subsequently evolving into the mitochondrial organelle of our cells. The consensus is based upon genetic and metabolic similarities between mitochondria and aerobic α proteobacteria but fails to explain the origin of several enzymes found in the mitochondria-derived organelles of anaerobic eukaryotes such as Trichomonas and Entamoeba. These enzymes are thought to derive from bacterial lineages other than α proteobacteria, e.g., Clostridium - an obligate anaerobe. [FeFe]-hydrogenase constitues the characteristic enzyme of this anaerobic metabolism and is present in different types also in Entamoeba and other anaerobic eukaryotes. Here we show that α proteobacteria derived from metagenomic studies possess both the cytosolic and organellar type of [FeFe]-hydrogenase, as well as all the proteins required for hydrogenase maturation. These organisms are related to cultivated members of the Rhodospirillales order previously suggested to be close relatives of mitochondrial ancestors. For the first time, our evidence supports an α proteobacterial ancestry for both the anaerobic and the aerobic metabolism of eukaryotes.REVIEWERS: This article was reviewed by William Martin and Nick Lane, both suggested by the Authors.
KW - Alphaproteobacteria/genetics
KW - Amino Acid Sequence
KW - Bacterial Proteins/genetics
KW - Evolution, Molecular
KW - Gastrointestinal Microbiome/genetics
KW - Humans
KW - Hydrogenase/genetics
KW - Phylogeny
KW - Rhodospirillaceae/genetics
U2 - 10.1186/s13062-016-0136-3
DO - 10.1186/s13062-016-0136-3
M3 - Journal article
C2 - 27473689
VL - 11
SP - 34
JO - Biology Direct
JF - Biology Direct
SN - 1745-6150
ER -
ID: 214021923