TY - JOUR

T1 - Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

T2 - Results from The BRCA1 and BRCA2 Cohort Consortium

AU - Li, Hongyan

AU - Terry, Mary Beth

AU - Antoniou, Antonis C

AU - Phillips, Kelly-Anne

AU - Kast, Karin

AU - Mooij, Thea M

AU - Engel, Christoph

AU - Noguès, Catherine

AU - Stoppa-Lyonnet, Dominique

AU - Lasset, Christine

AU - Berthet, Pascaline

AU - Mari, Veronique

AU - Caron, Olivier

AU - Barrowdale, Daniel

AU - Frost, Debra

AU - Brewer, Carole

AU - Evans, D Gareth

AU - Izatt, Louise

AU - Side, Lucy

AU - Walker, Lisa

AU - Tischkowitz, Marc

AU - Rogers, Mark T

AU - Porteous, Mary E

AU - Snape, Katie

AU - Meijers-Heijboer, Hanne E J

AU - Gille, Johan J P

AU - Blok, Marinus J

AU - Hoogerbrugge, Nicoline

AU - Daly, Mary B

AU - Andrulis, Irene L

AU - Buys, Saundra S

AU - John, Esther M

AU - McLachlan, Sue-Anne

AU - Friedlander, Michael

AU - Tan, Yen Y

AU - Osorio, Ana

AU - Caldes, Trinidad

AU - Jakubowska, Anna

AU - Simard, Jacques

AU - Singer, Christian F

AU - Olah, Edith

AU - Navratilova, Marie

AU - Foretova, Lenka

AU - Gerdes, Anne-Marie

AU - Roos-Blom, Marie-José

AU - Arver, Brita

AU - Olsson, Håkan

AU - Schmutzler, Rita K

AU - Hopper, John L

AU - Milne, Roger L

AU - GENEPSO study

N1 - ©2019 American Association for Cancer Research.

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential.METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 [95% confidence interval (CI), 1.02-1.39] and the HR from prospective analysis (HRP) was 1.36 (95% CI, 0.99-1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR = 1.25; 95% CI, 1.01-1.55 and HRP = 1.30; 95% CI, 0.83-2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk.CONCLUSIONS: The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.

AB - BACKGROUND: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential.METHODS: Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models.RESULTS: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 [95% confidence interval (CI), 1.02-1.39] and the HR from prospective analysis (HRP) was 1.36 (95% CI, 0.99-1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR = 1.25; 95% CI, 1.01-1.55 and HRP = 1.30; 95% CI, 0.83-2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk.CONCLUSIONS: The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.IMPACT: This is the largest prospective study of BRCA mutation carriers to assess these important risk factors.

U2 - 10.1158/1055-9965.EPI-19-0546

DO - 10.1158/1055-9965.EPI-19-0546

M3 - Journal article

C2 - 31792088

VL - 29

SP - 368

EP - 378

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 2

ER -