Age-stratified longitudinal study of Alzheimer's and vascular dementia patients
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. / Jørgensen, Isabella Friis; Aguayo-Orozco, Alejandro; Lademann, Mette; Brunak, Søren.
I: Alzheimer's & Dementia, 2020, s. 908-917.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Age-stratified longitudinal study of Alzheimer's and vascular dementia patients
AU - Jørgensen, Isabella Friis
AU - Aguayo-Orozco, Alejandro
AU - Lademann, Mette
AU - Brunak, Søren
PY - 2020
Y1 - 2020
N2 - INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.RESULTS: We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns before the dementia diagnosis. Stratifying patients by age and reducing the comorbidity space to two dimensions, showed better discrimination between AD and VaD patients in early-onset dementia.DISCUSSION: Similar age-associated comorbidities, the phenomenon of mixed dementia, and misdiagnosis create great challenges in discriminating between classical subtypes of dementia.
AB - INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.RESULTS: We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns before the dementia diagnosis. Stratifying patients by age and reducing the comorbidity space to two dimensions, showed better discrimination between AD and VaD patients in early-onset dementia.DISCUSSION: Similar age-associated comorbidities, the phenomenon of mixed dementia, and misdiagnosis create great challenges in discriminating between classical subtypes of dementia.
U2 - 10.1002/alz.12091
DO - 10.1002/alz.12091
M3 - Journal article
C2 - 32342671
SP - 908
EP - 917
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
SN - 1552-5260
ER -
ID: 240408061