TY - JOUR

T1 - Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients

T2 - EPICOVIDEHA findings

AU - Rossi, Giuseppe

AU - Salmanton-García, Jon

AU - Cattaneo, Chiara

AU - Marchesi, Francesco

AU - Dávila-Valls, Julio

AU - Martín-Pérez, Sonia

AU - Itri, Federico

AU - López-García, Alberto

AU - Glenthøj, Andreas

AU - da Silva, Maria Gomes

AU - Besson, Caroline

AU - Marchetti, Monia

AU - Weinbergerová, Barbora

AU - Jaksic, Ozren

AU - Jiménez, Moraima

AU - Bilgin, Yavuz M.

AU - Van Doesum, Jaap

AU - Farina, Francesca

AU - Žák, Pavel

AU - Verga, Luisa

AU - Collins, Graham P.

AU - Bonuomo, Valentina

AU - Van Praet, Jens

AU - Nucci, Marcio

AU - Meers, Stef

AU - Espigado, Ildefonso

AU - Fracchiolla, Nicola S.

AU - Valković, Toni

AU - Poulsen, Christian Bjørn

AU - Čolović, Natasha

AU - Dragonetti, Giulia

AU - Ledoux, Marie Pierre

AU - Tascini, Carlo

AU - Buquicchio, Caterina

AU - Blennow, Ola

AU - Passamonti, Francesco

AU - Machado, Marina

AU - Labrador, Jorge

AU - Duarte, Rafael F.

AU - Schönlein, Martin

AU - Prezioso, Lucia

AU - Falces-Romero, Iker

AU - Kulasekararaj, Austin

AU - Garcia-Vidal, Carolina

AU - Fernández, Noemí

AU - Abu-Zeinah, Ghaith

AU - Ormazabal-Vélez, Irati

AU - Adžić-Vukičević, Tatjana

AU - Piukovics, Klára

AU - Stoma, Igor

AU - Cuccaro, Annarosa

AU - Magliano, Gabriele

AU - Szotkowski, Tomáš

AU - González-López, Tomás José

AU - El-Ashwah, Shaimaa

AU - Bergantim, Rui

AU - Sili, Uluhan

AU - Maertens, Johan

AU - Demirkan, Fatih

AU - De Ramón, Cristina

AU - Petzer, Verena

AU - Del Principe, Maria Ilaria

AU - Navrátil, Milan

AU - Dargenio, Michelina

AU - Seval, Guldane Cengiz

AU - Samarkos, Michail

AU - Ráčil, Zdeněk

AU - Pinczés, László Imre

AU - Lahmer, Tobias

AU - Busca, Alessandro

AU - Méndez, Gustavo Adolfo

AU - Vena, Antonio

AU - Biernat, Monika M.

AU - Merelli, Maria

AU - Calbacho, Maria

AU - Barać, Aleksandra

AU - Bavastro, Martina

AU - Limongelli, Alessandro

AU - Ilhan, Osman

AU - Wolf, Dominik

AU - Çolak, Gökçe Melis

AU - García-Sanz, Ramón

AU - Emarah, Ziad

AU - Mišković, Bojana

AU - Gräfe, Stefanie K.

AU - Mladenović, Miloš

AU - Aiello, Tommaso Francesco

AU - Núñez-Martín-Buitrago, Lucía

AU - Nordlander, Anna

AU - Arellano, Elena

AU - Zambrotta, Giovanni Paolo Maria

AU - Ammatuna, Emanuele

AU - Cabirta, Alba

AU - Sacchi, Maria Vittoria

AU - Rodrigues, Raquel Nunes

AU - Hersby, Ditte Stampe

AU - Hanakova, Michaela

AU - Rahimli, Laman

AU - Cordoba, Raul

AU - Cornely, Oliver A.

AU - Pagano, Livio

AU - Marques De Almeida, Joyce

AU - Hernández-Rivas, José Ángel

AU - Guidetti, Anna

AU - Finizio, Olimpia

AU - Stojanoski, Zlate

AU - Cvetanoski, Milche

AU - Meletiadis, Joseph

AU - de Jonge, Nick

AU - Antić, Darko

AU - Ali, Natasha

AU - Tisi, Maria Chiara

AU - Serrano, Laura

AU - Plantefeve, Gaëtan

AU - Khanna, Nina

AU - Hoenigl, Martin

AU - Čerňan, Martin

AU - Miranda-Castillo, Carolina

AU - Fernández-Galán, María

AU - Ser-Ris, Alexandra

AU - Erben, Nurettin

AU - Duléry, Rémy

AU - Aujayeb, Avinash

AU - Papa, Mario Virgilio

AU - Novák, Jan

AU - Delia, Mario

AU - Sapienza, Giuseppe

AU - Reizine, Florian

AU - Omrani, Ali S.

AU - Di Blasi, Roberta

AU - Lamure, Sylvain

AU - Drgoňa, Ľuboš

AU - Coppola, Nicola

AU - Batinić, Josip

AU - Al-Khabori, Murtadha

AU - Ribera-Santa Susana, José María

AU - Piedimonte, Monica

AU - Loureiro-Amigo, Jorge

AU - Fouquet, Guillemette

AU - Fazzi, Rita

AU - Danion, François

AU - Schubert, Jörg

AU - Hoell-Neugebauer, Baerbel

AU - Bahr, Nathan C.

AU - Yahia, Ayel Omar

AU - Torres-Atienza, Ana

AU - Rinaldi, Ikhwan

AU - Popova, Marina

AU - Ommen, Hans Beier

AU - Mitra, Maria Enza

AU - Mikulska, Malgorzata

AU - Lacej, Ira

AU - Khostelidi, Sofya

AU - Win, Sein

AU - Vinh, Donald

AU - Saleh, Modar

AU - Prattes, Juergen

AU - Jindra, Pavel

AU - Guolo, Fabio

AU - della Pepa, Roberta

AU - Chelysheva, Ekaterina

AU - Zdziarski, Przemyslaw

AU - Wai-Man, Vivien

AU - Soto-Silva, Andrés

AU - Orth, Hans Martin

AU - Malak, Sandra

AU - Lorenzo De La Peña, Lisset

AU - Kolditz, Martin

AU - Kho, Chi Shan

AU - Heath, Christopher H.

AU - Groh, Ana

AU - Gavriilaki, Eleni

AU - Fung, Monica

AU - Egger, Matthias

AU - de Kort, Elizabeth

AU - de Cabo, Erik

AU - Cushion, Tania

AU - Chowdhury, Fazle Rabbi

AU - Ceesay, M. Mansour

AU - Brehon, Mathias

AU - Varricchio, Gina

AU - Tafuri, Agostino

AU - Jiménez-Lorenzo, María Josefa

AU - Klimko, Nikolai

AU - Tsirigotis, Panagiotis

AU - Antoniadou, Anastasia

AU - Vehreschild, Maria

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

AB - Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

KW - COVID-19

KW - Elderly

KW - Hematological malignancy

KW - High-risk patient

KW - SARS-CoV-2

U2 - 10.1016/j.ijid.2023.10.013

DO - 10.1016/j.ijid.2023.10.013

M3 - Journal article

C2 - 37863310

AN - SCOPUS:85176106626

VL - 137

SP - 98

EP - 110

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -