Affinity ligand development in six weeks
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Affinity ligand development in six weeks. / Christensen, Soren F.; Meldal, Morten.
I: Genetic Engineering News, Bind 25, Nr. 7, 01.04.2005, s. 58-59.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Affinity ligand development in six weeks
AU - Christensen, Soren F.
AU - Meldal, Morten
PY - 2005/4/1
Y1 - 2005/4/1
N2 - We have presented the encoded beads technology for fast development of affinity ligands for purification of biopharmaceuticals. The technology is based on solid-phase combinatorial synthesis of affinity ligands, where each ligand is bound to a polymer bead. The unique feature of the encoded beads technology is the fact that every polymer bead holds one affinity ligand and one code. In this way simply reading the code of the bead derives the exact chemical structure of the affinity ligand bound to any bead (Figure 4). This eliminates the need for traditional spectroscopic analysis and enables screening of a whole combinatorial library of affinity ligands in just one week (Step 4). A first set of specific affinity ligands can be developed in six weeks (Steps 1 through 4).
AB - We have presented the encoded beads technology for fast development of affinity ligands for purification of biopharmaceuticals. The technology is based on solid-phase combinatorial synthesis of affinity ligands, where each ligand is bound to a polymer bead. The unique feature of the encoded beads technology is the fact that every polymer bead holds one affinity ligand and one code. In this way simply reading the code of the bead derives the exact chemical structure of the affinity ligand bound to any bead (Figure 4). This eliminates the need for traditional spectroscopic analysis and enables screening of a whole combinatorial library of affinity ligands in just one week (Step 4). A first set of specific affinity ligands can be developed in six weeks (Steps 1 through 4).
UR - http://www.scopus.com/inward/record.url?scp=17144364713&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:17144364713
VL - 25
SP - 58
EP - 59
JO - Genetic Engineering and Biotechnology News
JF - Genetic Engineering and Biotechnology News
SN - 1935-472X
IS - 7
ER -
ID: 326847540