Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database
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Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis : A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database. / Engjom, Trond; Nordaas, Ingrid Kvåle; Tjora, Erling; Dimcevski, Georg; Haldorsen, Ingfrid Salvesen; Olesen, Søren Schou; Drewes, Asbjørn Mohr; Zviniene, Kristina; Barauskas, Giedrus; Riis Jespersen, Hans Søe; Jensen, Nanna; Borch, Anders; Nøjgaard, Camilla; Novovic, Srdan; Kardasheva, Svetlana S.; Okhlobystin, Alexey; Hauge, Truls; Waage, Anne; Frøkjær, Jens Brøndum.
I: Pancreatology, Bind 21, Nr. 4, 01.06.2021, s. 688-697.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis
T2 - A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database
AU - Engjom, Trond
AU - Nordaas, Ingrid Kvåle
AU - Tjora, Erling
AU - Dimcevski, Georg
AU - Haldorsen, Ingfrid Salvesen
AU - Olesen, Søren Schou
AU - Drewes, Asbjørn Mohr
AU - Zviniene, Kristina
AU - Barauskas, Giedrus
AU - Riis Jespersen, Hans Søe
AU - Jensen, Nanna
AU - Borch, Anders
AU - Nøjgaard, Camilla
AU - Novovic, Srdan
AU - Kardasheva, Svetlana S.
AU - Okhlobystin, Alexey
AU - Hauge, Truls
AU - Waage, Anne
AU - Frøkjær, Jens Brøndum
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Objectives: The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP. Methods: Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features. Results: We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]). Conclusion: In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.
AB - Objectives: The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP. Methods: Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features. Results: We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]). Conclusion: In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.
KW - Aetiology
KW - Chronic pancreatitis
KW - Imaging
KW - Risk factor
U2 - 10.1016/j.pan.2021.02.023
DO - 10.1016/j.pan.2021.02.023
M3 - Tidsskriftartikel
C2 - 33707113
VL - 21
SP - 688
EP - 697
JO - Pancreatology
JF - Pancreatology
SN - 1424-3903
IS - 4
ER -
ID: 285879773