TY - JOUR

T1 - Acute exercise-induced changes in basal VLDL-triglyceride kinetics leading to hypotriglyceridemia manifest more readily after resistance than endurance exercise

AU - Magkos, Faidon

AU - Tsekouras, Yiannis E

AU - Prentzas, Konstantinos I

AU - Basioukas, Konstantinos N

AU - Matsama, Stergoula G

AU - Yanni, Amalia E

AU - Kavouras, Stavros A

AU - Sidossis, Labros S

N1 - (Ekstern)

PY - 2008

Y1 - 2008

N2 - Resistance training is considered less effective than endurance training in lowering plasma triglyceride (TG) concentrations. Acutely, however, a single bout of strenuous exercise, whether endurance or resistance, increases the efficiency of very low-density lipoprotein (VLDL)-TG removal from the circulation and leads to hypotriglyceridemia. The comparative effects of these two types of exercise on VLDL-TG metabolism are not known. We therefore examined basal VLDL-TG kinetics by using stable isotope-labeled tracers in seven healthy, nonobese, untrained young men in the postabsorptive state, the morning after a single 90-min bout of either low-intensity endurance exercise (approximately 30% of peak oxygen consumption) or high-intensity resistance exercise (3 sets of 10 repetitions for 12 exercises at 80% of peak torque production), matched for total energy expenditure (approximately 400 kcal), or an equivalent period of rest on the preceding afternoon. Compared with rest, resistance exercise lowered fasting plasma VLDL-TG concentration by -28 +/- 10% (P = 0.034), increased VLDL-TG plasma clearance rate by 30 +/- 8% (P = 0.003), and shortened the mean residence time (MRT) of VLDL-TG in the circulation by -36 +/- 11 min (P = 0.016), whereas endurance exercise had no effect (all P > 0.05). Basal VLDL-TG plasma clearance rate was greater (P = 0.003) and VLDL-TG MRT was shorter (P = 0.012) the morning after resistance than endurance exercise. We conclude that, for the same total energy expenditure, resistance exercise is more potent than endurance exercise in eliciting changes in VLDL-TG metabolism that have been linked with hypotriglyceridemia, and it should thus be considered as an alternative to or in addition to endurance exercise for the control of plasma TG concentrations.

AB - Resistance training is considered less effective than endurance training in lowering plasma triglyceride (TG) concentrations. Acutely, however, a single bout of strenuous exercise, whether endurance or resistance, increases the efficiency of very low-density lipoprotein (VLDL)-TG removal from the circulation and leads to hypotriglyceridemia. The comparative effects of these two types of exercise on VLDL-TG metabolism are not known. We therefore examined basal VLDL-TG kinetics by using stable isotope-labeled tracers in seven healthy, nonobese, untrained young men in the postabsorptive state, the morning after a single 90-min bout of either low-intensity endurance exercise (approximately 30% of peak oxygen consumption) or high-intensity resistance exercise (3 sets of 10 repetitions for 12 exercises at 80% of peak torque production), matched for total energy expenditure (approximately 400 kcal), or an equivalent period of rest on the preceding afternoon. Compared with rest, resistance exercise lowered fasting plasma VLDL-TG concentration by -28 +/- 10% (P = 0.034), increased VLDL-TG plasma clearance rate by 30 +/- 8% (P = 0.003), and shortened the mean residence time (MRT) of VLDL-TG in the circulation by -36 +/- 11 min (P = 0.016), whereas endurance exercise had no effect (all P > 0.05). Basal VLDL-TG plasma clearance rate was greater (P = 0.003) and VLDL-TG MRT was shorter (P = 0.012) the morning after resistance than endurance exercise. We conclude that, for the same total energy expenditure, resistance exercise is more potent than endurance exercise in eliciting changes in VLDL-TG metabolism that have been linked with hypotriglyceridemia, and it should thus be considered as an alternative to or in addition to endurance exercise for the control of plasma TG concentrations.

KW - Adult

KW - Blood Glucose/metabolism

KW - Carbohydrate Metabolism

KW - Down-Regulation

KW - Energy Metabolism

KW - Exercise

KW - Humans

KW - Hypolipoproteinemias/metabolism

KW - Insulin/blood

KW - Kinetics

KW - Lipid Metabolism

KW - Lipoproteins, VLDL/blood

KW - Liver/metabolism

KW - Male

KW - Oxidation-Reduction

KW - Physical Endurance

KW - Triglycerides/blood

U2 - 10.1152/japplphysiol.90761.2008

DO - 10.1152/japplphysiol.90761.2008

M3 - Journal article

C2 - 18669933

VL - 105

SP - 1228

EP - 1236

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -