Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum. / Sørensen, Andreas T; Kanter-Schlifke, Irene; Lin, En-Ju D; During, Matthew J; Kokaia, Merab.

I: Molecular and Cellular Neuroscience, Bind 39, Nr. 2, 10.2008, s. 229-37.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sørensen, AT, Kanter-Schlifke, I, Lin, E-JD, During, MJ & Kokaia, M 2008, 'Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum', Molecular and Cellular Neuroscience, bind 39, nr. 2, s. 229-37. https://doi.org/10.1016/j.mcn.2008.06.014

APA

Sørensen, A. T., Kanter-Schlifke, I., Lin, E-J. D., During, M. J., & Kokaia, M. (2008). Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum. Molecular and Cellular Neuroscience, 39(2), 229-37. https://doi.org/10.1016/j.mcn.2008.06.014

Vancouver

Sørensen AT, Kanter-Schlifke I, Lin E-JD, During MJ, Kokaia M. Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum. Molecular and Cellular Neuroscience. 2008 okt.;39(2):229-37. https://doi.org/10.1016/j.mcn.2008.06.014

Author

Sørensen, Andreas T ; Kanter-Schlifke, Irene ; Lin, En-Ju D ; During, Matthew J ; Kokaia, Merab. / Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum. I: Molecular and Cellular Neuroscience. 2008 ; Bind 39, Nr. 2. s. 229-37.

Bibtex

@article{7d278d8ea4d9405e95e3c1d4590773a0,

title = "Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum",

abstract = "Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms governing the release and action of transgene NPY in neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY gene, transgene NPY is released during high-frequency activation of CA1-subicular synapses. Released transgene NPY attenuates excitatory synaptic transmission not only in activated, but also in neighboring, non-activated synapses. Such broad action of transgene NPY may prevent recruitment of excitatory synapses in epileptic activity and could play a key role in limiting the spread and generalization of seizures.",

keywords = "Animals, Animals, Newborn, Arginine, Benzazepines, Biophysical Phenomena, Chi-Square Distribution, Electric Stimulation, Excitatory Postsynaptic Potentials, Female, GABA Antagonists, Genetic Vectors, Glutamic Acid, Green Fluorescent Proteins, Hippocampus, In Vitro Techniques, Long-Term Potentiation, Male, Neurons, Neuropeptide Y, Patch-Clamp Techniques, Phosphopyruvate Hydratase, Picrotoxin, Rats, Rats, Sprague-Dawley, Receptors, Neuropeptide Y, Tetrodotoxin, Transgenes, Journal Article, Research Support, Non-U.S. Gov't",

author = "S{\o}rensen, {Andreas T} and Irene Kanter-Schlifke and Lin, {En-Ju D} and During, {Matthew J} and Merab Kokaia",

year = "2008",

month = oct,

doi = "10.1016/j.mcn.2008.06.014",

language = "English",

volume = "39",

pages = "229--37",

journal = "Molecular and Cellular Neurosciences",

issn = "1044-7431",

publisher = "Academic Press",

number = "2",

}

RIS

TY - JOUR

T1 - Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

AU - Sørensen, Andreas T

AU - Kanter-Schlifke, Irene

AU - Lin, En-Ju D

AU - During, Matthew J

AU - Kokaia, Merab

PY - 2008/10

Y1 - 2008/10

N2 - Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms governing the release and action of transgene NPY in neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY gene, transgene NPY is released during high-frequency activation of CA1-subicular synapses. Released transgene NPY attenuates excitatory synaptic transmission not only in activated, but also in neighboring, non-activated synapses. Such broad action of transgene NPY may prevent recruitment of excitatory synapses in epileptic activity and could play a key role in limiting the spread and generalization of seizures.

AB - Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms governing the release and action of transgene NPY in neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY gene, transgene NPY is released during high-frequency activation of CA1-subicular synapses. Released transgene NPY attenuates excitatory synaptic transmission not only in activated, but also in neighboring, non-activated synapses. Such broad action of transgene NPY may prevent recruitment of excitatory synapses in epileptic activity and could play a key role in limiting the spread and generalization of seizures.

KW - Animals

KW - Animals, Newborn

KW - Arginine

KW - Benzazepines

KW - Biophysical Phenomena

KW - Chi-Square Distribution

KW - Electric Stimulation

KW - Excitatory Postsynaptic Potentials

KW - Female

KW - GABA Antagonists

KW - Genetic Vectors

KW - Glutamic Acid

KW - Green Fluorescent Proteins

KW - Hippocampus

KW - In Vitro Techniques

KW - Long-Term Potentiation

KW - Male

KW - Neurons

KW - Neuropeptide Y

KW - Patch-Clamp Techniques

KW - Phosphopyruvate Hydratase

KW - Picrotoxin

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Neuropeptide Y

KW - Tetrodotoxin

KW - Transgenes

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.mcn.2008.06.014

DO - 10.1016/j.mcn.2008.06.014

M3 - Journal article

C2 - 18652899

VL - 39

SP - 229

EP - 237

JO - Molecular and Cellular Neurosciences

JF - Molecular and Cellular Neurosciences

SN - 1044-7431

IS - 2

ER -

ID: 186411872