Abnormal atrial activation in young patients with lone atrial fibrillation
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Abnormal atrial activation in young patients with lone atrial fibrillation. / Holmqvist, Fredrik; Olesen, Morten S; Tveit, Arnljot; Enger, Steve; Tapanainen, Jari; Jurkko, Raija; Havmöller, Rasmus; Haunsø, Stig; Carlson, Jonas; Svendsen, Jesper Hastrup; Platonov, Pyotr G; Holmqvist, Fredrik; Olesen, Morten S; Tveit, Arnljot; Enger, Steve; Tapanainen, Jari; Jurkko, Raija; Havmöller, Rasmus; Haunsø, Stig; Carlson, Jonas; Svendsen, Jesper H; Platonov, Pyotr G.
I: Europace, Bind 13, Nr. 2, 2011, s. 188-92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Abnormal atrial activation in young patients with lone atrial fibrillation
AU - Holmqvist, Fredrik
AU - Olesen, Morten S
AU - Tveit, Arnljot
AU - Enger, Steve
AU - Tapanainen, Jari
AU - Jurkko, Raija
AU - Havmöller, Rasmus
AU - Haunsø, Stig
AU - Carlson, Jonas
AU - Svendsen, Jesper Hastrup
AU - Platonov, Pyotr G
AU - Holmqvist, Fredrik
AU - Olesen, Morten S
AU - Tveit, Arnljot
AU - Enger, Steve
AU - Tapanainen, Jari
AU - Jurkko, Raija
AU - Havmöller, Rasmus
AU - Haunsø, Stig
AU - Carlson, Jonas
AU - Svendsen, Jesper H
AU - Platonov, Pyotr G
PY - 2011
Y1 - 2011
N2 - Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (34 ± 4 years, 34 men) and compared with age- and gender-matched control subjects. Standard 12-lead electrocardiogram (ECG) was recorded for at least 10 s. P-wave morphology and duration were estimated using signal-averaged P-wave analysis. Echocardiography was performed in association with the ECG recording. Heart rate (67 ± 13 vs. 65 ± 7 b.p.m., P = 0.800) and PQ-interval (163 ± 16 vs. 164 ± 23 ms, P = 0.629) were similar in AF cases and controls, as was P-wave duration (136 ± 13 vs. 129 ± 13 ms, P = 0.107). The distribution of P-wave morphology differed between the AF cases and controls [33/58/0/8 vs. 75/25/0/0% (Type 1/Type 2/Type 3/atypical), P = 0.001], with a larger proportion of patients with AF exhibiting signs of impaired interatrial conduction. Conclusion A significant difference in P-wave morphology distribution was seen between patients with early-onset, lone paroxysmal AF and age- and gender-matched healthy control subjects. This finding indicates that alterations in atrial electrophysiology are common in the early stage of the arrhythmia, and since it occurs in young patients without co-morbidity may well be the cause rather than the consequence of AF.
AB - Aims Patients with a history of atrial fibrillation (AF) have previously been shown to have altered atrial conduction, as seen non-invasively using signal-averaged P-wave analysis. However, little is known about the P-wave morphology in patients in the early phases of AF with structurally normal hearts. Methods and results Thirty-six patients with lone AF were included before the age of 40 years (34 ± 4 years, 34 men) and compared with age- and gender-matched control subjects. Standard 12-lead electrocardiogram (ECG) was recorded for at least 10 s. P-wave morphology and duration were estimated using signal-averaged P-wave analysis. Echocardiography was performed in association with the ECG recording. Heart rate (67 ± 13 vs. 65 ± 7 b.p.m., P = 0.800) and PQ-interval (163 ± 16 vs. 164 ± 23 ms, P = 0.629) were similar in AF cases and controls, as was P-wave duration (136 ± 13 vs. 129 ± 13 ms, P = 0.107). The distribution of P-wave morphology differed between the AF cases and controls [33/58/0/8 vs. 75/25/0/0% (Type 1/Type 2/Type 3/atypical), P = 0.001], with a larger proportion of patients with AF exhibiting signs of impaired interatrial conduction. Conclusion A significant difference in P-wave morphology distribution was seen between patients with early-onset, lone paroxysmal AF and age- and gender-matched healthy control subjects. This finding indicates that alterations in atrial electrophysiology are common in the early stage of the arrhythmia, and since it occurs in young patients without co-morbidity may well be the cause rather than the consequence of AF.
U2 - 10.1093/europace/euq352
DO - 10.1093/europace/euq352
M3 - Journal article
C2 - 20864492
VL - 13
SP - 188
EP - 192
JO - Europace
JF - Europace
SN - 1099-5129
IS - 2
ER -
ID: 32476297