Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
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Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. / Christiansen, Malene Revsbech; Kilpelöainen, Tuomas O.; McCaffery, Jeanne M.
I: Diabetes, Bind 72, Nr. 10, 2023, s. 1424-1432.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
AU - Christiansen, Malene Revsbech
AU - Kilpelöainen, Tuomas O.
AU - McCaffery, Jeanne M.
N1 - Publisher Copyright: © 2023 by the American Diabetes Association.
PY - 2023
Y1 - 2023
N2 - Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.
AB - Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.
U2 - 10.2337/db23-0131
DO - 10.2337/db23-0131
M3 - Journal article
C2 - 37494631
AN - SCOPUS:85171901479
VL - 72
SP - 1424
EP - 1432
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 10
ER -
ID: 369122016