A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

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Standard

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. / Johnston, Chris J. C.; Smyth, Danielle J.; Kodali, Ravindra B.; White, Madeleine P. J.; Harcus, Yvonne; Filbey, Kara J.; Hewitson, James P.; Hinck, Cynthia S.; Ivens, Alasdair; Kemter, Andrea M.; Kildemoes, Anna O.; Le Bihan, Thierry; Soares, Dinesh C.; Anderton, Stephen M.; Brenn, Thomas; Wigmore, Stephen J.; Woodcock, Hannah V.; Chambers, Rachel C.; Hinck, Andrew P.; Mcsorley, Henry J.; Maizels, Rick M.

I: Nature Communications, Bind 8, Nr. 1, 1741, 23.11.2017.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Johnston, CJC, Smyth, DJ, Kodali, RB, White, MPJ, Harcus, Y, Filbey, KJ, Hewitson, JP, Hinck, CS, Ivens, A, Kemter, AM, Kildemoes, AO, Le Bihan, T, Soares, DC, Anderton, SM, Brenn, T, Wigmore, SJ, Woodcock, HV, Chambers, RC, Hinck, AP, Mcsorley, HJ & Maizels, RM 2017, 'A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells', Nature Communications, bind 8, nr. 1, 1741. https://doi.org/10.1038/s41467-017-01886-6

APA

Johnston, C. J. C., Smyth, D. J., Kodali, R. B., White, M. P. J., Harcus, Y., Filbey, K. J., Hewitson, J. P., Hinck, C. S., Ivens, A., Kemter, A. M., Kildemoes, A. O., Le Bihan, T., Soares, D. C., Anderton, S. M., Brenn, T., Wigmore, S. J., Woodcock, H. V., Chambers, R. C., Hinck, A. P., ... Maizels, R. M. (2017). A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 8(1), [1741]. https://doi.org/10.1038/s41467-017-01886-6

Vancouver

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ o.a. A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications. 2017 nov. 23;8(1). 1741. https://doi.org/10.1038/s41467-017-01886-6

Author

Johnston, Chris J. C. ; Smyth, Danielle J. ; Kodali, Ravindra B. ; White, Madeleine P. J. ; Harcus, Yvonne ; Filbey, Kara J. ; Hewitson, James P. ; Hinck, Cynthia S. ; Ivens, Alasdair ; Kemter, Andrea M. ; Kildemoes, Anna O. ; Le Bihan, Thierry ; Soares, Dinesh C. ; Anderton, Stephen M. ; Brenn, Thomas ; Wigmore, Stephen J. ; Woodcock, Hannah V. ; Chambers, Rachel C. ; Hinck, Andrew P. ; Mcsorley, Henry J. ; Maizels, Rick M. / A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. I: Nature Communications. 2017 ; Bind 8, Nr. 1.

Bibtex

@article{672b342d71f94e41b20b91e8a075c617,
title = "A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells",
abstract = "Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.",
author = "Johnston, {Chris J. C.} and Smyth, {Danielle J.} and Kodali, {Ravindra B.} and White, {Madeleine P. J.} and Yvonne Harcus and Filbey, {Kara J.} and Hewitson, {James P.} and Hinck, {Cynthia S.} and Alasdair Ivens and Kemter, {Andrea M.} and Kildemoes, {Anna O.} and {Le Bihan}, Thierry and Soares, {Dinesh C.} and Anderton, {Stephen M.} and Thomas Brenn and Wigmore, {Stephen J.} and Woodcock, {Hannah V.} and Chambers, {Rachel C.} and Hinck, {Andrew P.} and Mcsorley, {Henry J.} and Maizels, {Rick M.}",
year = "2017",
month = nov,
day = "23",
doi = "10.1038/s41467-017-01886-6",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

AU - Johnston, Chris J. C.

AU - Smyth, Danielle J.

AU - Kodali, Ravindra B.

AU - White, Madeleine P. J.

AU - Harcus, Yvonne

AU - Filbey, Kara J.

AU - Hewitson, James P.

AU - Hinck, Cynthia S.

AU - Ivens, Alasdair

AU - Kemter, Andrea M.

AU - Kildemoes, Anna O.

AU - Le Bihan, Thierry

AU - Soares, Dinesh C.

AU - Anderton, Stephen M.

AU - Brenn, Thomas

AU - Wigmore, Stephen J.

AU - Woodcock, Hannah V.

AU - Chambers, Rachel C.

AU - Hinck, Andrew P.

AU - Mcsorley, Henry J.

AU - Maizels, Rick M.

PY - 2017/11/23

Y1 - 2017/11/23

N2 - Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.

AB - Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the identity of the active molecule is unknown. Here we identify an H. polygyrus TGF-β mimic (Hp-TGM) that replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing mouse and human Foxp3+ Treg cells. Hp-TGM has no homology with mammalian TGF-β or other members of the TGF-β family, but is a member of the complement control protein superfamily. Thus, our data indicate that through convergent evolution, the parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.

U2 - 10.1038/s41467-017-01886-6

DO - 10.1038/s41467-017-01886-6

M3 - Journal article

C2 - 29170498

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1741

ER -

ID: 186042031