A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees. / Nielsen, Rasmus; Bustamente, Carlos; Clark, Andrew G.; Glanowski, Stephen; Sackton, Timothy B.; Hubisz, Melissa J.; Fledel-Alon, Adi; Tanenbaum, David M.; Civello, Daniel; White, Thomas J.; Sninsky, John J.; Adams, Mark D.; Cargill, Michele.
I: PLoS - Biology, Bind 3, Nr. 6, 2005, s. e170.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
AU - Nielsen, Rasmus
AU - Bustamente, Carlos
AU - Clark, Andrew G.
AU - Glanowski, Stephen
AU - Sackton, Timothy B.
AU - Hubisz, Melissa J.
AU - Fledel-Alon, Adi
AU - Tanenbaum, David M.
AU - Civello, Daniel
AU - White, Thomas J.
AU - Sninsky, John J.
AU - Adams, Mark D.
AU - Cargill, Michele
PY - 2005
Y1 - 2005
N2 - Since the divergence of humans and chimpanzees about 5 million years ago, these species have undergone a remarkable evolution with drastic divergence in anatomy and cognitive abilities. At the molecular level, despite the small overall magnitude of DNA sequence divergence, we might expect such evolutionary changes to leave a noticeable signature throughout the genome. We here compare 13,731 annotated genes from humans to their chimpanzee orthologs to identify genes that show evidence of positive selection. Many of the genes that present a signature of positive selection tend to be involved in sensory perception or immune defenses. However, the group of genes that show the strongest evidence for positive selection also includes a surprising number of genes involved in tumor suppression and apoptosis, and of genes involved in spermatogenesis. We hypothesize that positive selection in some of these genes may be driven by genomic conflict due to apoptosis during spermatogenesis. Genes with maximal expression in the brain show little or no evidence for positive selection, while genes with maximal expression in the testis tend to be enriched with positively selected genes. Genes on the X chromosome also tend to show an elevated tendency for positive selection. We also present polymorphism data from 20 Caucasian Americans and 19 African Americans for the 50 annotated genes showing the strongest evidence for positive selection. The polymorphism analysis further supports the presence of positive selection in these genes by showing an excess of high-frequency derived nonsynonymous mutations.
AB - Since the divergence of humans and chimpanzees about 5 million years ago, these species have undergone a remarkable evolution with drastic divergence in anatomy and cognitive abilities. At the molecular level, despite the small overall magnitude of DNA sequence divergence, we might expect such evolutionary changes to leave a noticeable signature throughout the genome. We here compare 13,731 annotated genes from humans to their chimpanzee orthologs to identify genes that show evidence of positive selection. Many of the genes that present a signature of positive selection tend to be involved in sensory perception or immune defenses. However, the group of genes that show the strongest evidence for positive selection also includes a surprising number of genes involved in tumor suppression and apoptosis, and of genes involved in spermatogenesis. We hypothesize that positive selection in some of these genes may be driven by genomic conflict due to apoptosis during spermatogenesis. Genes with maximal expression in the brain show little or no evidence for positive selection, while genes with maximal expression in the testis tend to be enriched with positively selected genes. Genes on the X chromosome also tend to show an elevated tendency for positive selection. We also present polymorphism data from 20 Caucasian Americans and 19 African Americans for the 50 annotated genes showing the strongest evidence for positive selection. The polymorphism analysis further supports the presence of positive selection in these genes by showing an excess of high-frequency derived nonsynonymous mutations.
U2 - 10.1371/journal.pbio.0030170
DO - 10.1371/journal.pbio.0030170
M3 - Journal article
C2 - 15869325
VL - 3
SP - e170
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 6
ER -
ID: 87656