TY - JOUR

T1 - A prospective PET study of patients with glioblastoma multiforme

AU - Andersen, Preben B.

AU - Blinkenberg, M

AU - Lassen, U

AU - Kosteljanetz, M

AU - Wagner, A

AU - Poulsen, H S

AU - Sørensen, P S

AU - Paulson, O B

PY - 2006/6

Y1 - 2006/6

N2 - OBJECTIVE: To study the post-surgical metabolic and structural cerebral changes in patients with glioblastoma multiforme (GBM).MATERIALS AND METHODS: We examined ten patients prospectively with newly diagnosed GBM. All patients were primarily treated with surgery, followed by chemotherapy (carmustine, cisplatine and etoposide) and radiotherapy. Positron emission tomography (PET) was used to measure tumor- and cerebral metabolism. CT or MRI was used to estimate tumor volume by measurements of tumor area.RESULTS: Tumor metabolism was not increased during chemotherapy (P = 0.71), but increased during radiotherapy (P = 0.01). CT/MRI showed similar results with no increase in tumor area during chemotherapy (P = 0.33) but increase during radiotherapy (P = 0.002). During the entire study, tumor metabolism and area increased evenly (P = 0.01).CONCLUSIONS: Our study did not show a gain of PET compared with structural imaging in the prospective evaluation of GBM. We found a difference in metabolic increase and tumor growth between the two treatment regimens, although this finding has limited relevance due to the design of the study.

AB - OBJECTIVE: To study the post-surgical metabolic and structural cerebral changes in patients with glioblastoma multiforme (GBM).MATERIALS AND METHODS: We examined ten patients prospectively with newly diagnosed GBM. All patients were primarily treated with surgery, followed by chemotherapy (carmustine, cisplatine and etoposide) and radiotherapy. Positron emission tomography (PET) was used to measure tumor- and cerebral metabolism. CT or MRI was used to estimate tumor volume by measurements of tumor area.RESULTS: Tumor metabolism was not increased during chemotherapy (P = 0.71), but increased during radiotherapy (P = 0.01). CT/MRI showed similar results with no increase in tumor area during chemotherapy (P = 0.33) but increase during radiotherapy (P = 0.002). During the entire study, tumor metabolism and area increased evenly (P = 0.01).CONCLUSIONS: Our study did not show a gain of PET compared with structural imaging in the prospective evaluation of GBM. We found a difference in metabolic increase and tumor growth between the two treatment regimens, although this finding has limited relevance due to the design of the study.

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Brain

KW - Brain Neoplasms

KW - Female

KW - Fluorodeoxyglucose F18

KW - Glioblastoma

KW - Glucose

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurosurgical Procedures

KW - Positron-Emission Tomography

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Radiotherapy

KW - Sample Size

KW - Treatment Outcome

KW - Clinical Trial

KW - Journal Article

U2 - 10.1111/j.1600-0404.2006.00628.x

DO - 10.1111/j.1600-0404.2006.00628.x

M3 - Journal article

C2 - 16674608

VL - 113

SP - 412

EP - 418

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 6

ER -