A Population- and Hospital-based Cross-sectional Study of Renal Function in Hidradenitis Suppurativa
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A Population- and Hospital-based Cross-sectional Study of Renal Function in Hidradenitis Suppurativa. / Miller, Iben M; Carlson, Nicholas; Mogensen, Ulla Brasch; Ellervik, Christina; Jemec, Gregor B E.
I: Acta Dermatovenereologica, Bind 96, 2016, s. 68–71.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A Population- and Hospital-based Cross-sectional Study of Renal Function in Hidradenitis Suppurativa
AU - Miller, Iben M
AU - Carlson, Nicholas
AU - Mogensen, Ulla Brasch
AU - Ellervik, Christina
AU - Jemec, Gregor B E
PY - 2016
Y1 - 2016
N2 - The chronic inflammatory skin diseases hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular risk factors and the latter has also been linked to possible renal dysfunction. Since basement membrane thinning in the skin of HS patients has been described, we speculated whether similar basement membrane defects might occur in renal tissue. Our objective was to investigate a possible association between HS and renal dysfunction. We performed a hospital and population-based cross-sectional study using estimated Glomerular-Filtration-Rate (eGFR) to assess renal function. Thirty-two hospital individuals with HS, 430 population individuals with HS, and 20, 780 population individuals without HS were identified. The age-sex-smoking-BMI-hypertension-diabetes adjusted analysis revealed a statistically significant higher eGFR for the hospital group with HS and a mean difference in eGFR of 6.81 (1.27-12.35) ml/min/1.73 m between the hospital group with HS and the population group without HS. The observed higher eGFR in the hospital group with HS indicates a possible association of HS and renal dysfunction.
AB - The chronic inflammatory skin diseases hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular risk factors and the latter has also been linked to possible renal dysfunction. Since basement membrane thinning in the skin of HS patients has been described, we speculated whether similar basement membrane defects might occur in renal tissue. Our objective was to investigate a possible association between HS and renal dysfunction. We performed a hospital and population-based cross-sectional study using estimated Glomerular-Filtration-Rate (eGFR) to assess renal function. Thirty-two hospital individuals with HS, 430 population individuals with HS, and 20, 780 population individuals without HS were identified. The age-sex-smoking-BMI-hypertension-diabetes adjusted analysis revealed a statistically significant higher eGFR for the hospital group with HS and a mean difference in eGFR of 6.81 (1.27-12.35) ml/min/1.73 m between the hospital group with HS and the population group without HS. The observed higher eGFR in the hospital group with HS indicates a possible association of HS and renal dysfunction.
U2 - 10.2340/00015555-2072
DO - 10.2340/00015555-2072
M3 - Journal article
C2 - 25710874
VL - 96
SP - 68
EP - 71
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
ER -
ID: 132135247