Standard
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. / Al Olama, Ali Amin; Kote-Jarai, Zsofia; Berndt, Sonja I; Conti, David V; Schumacher, Fredrick; Han, Ying; Benlloch, Sara; Hazelett, Dennis J; Wang, Zhaoming; Saunders, Ed; Leongamornlert, Daniel; Lindstrom, Sara; Jugurnauth-Little, Sara; Dadaev, Tokhir; Tymrakiewicz, Malgorzata; Stram, Daniel O; Rand, Kristin; Wan, Peggy; Stram, Alex; Sheng, Xin; Pooler, Loreall C; Park, Karen; Xia, Lucy; Tyrer, Jonathan; Kolonel, Laurence N; Le Marchand, Loic; Hoover, Robert N; Machiela, Mitchell J; Yeager, Merideth; Burdette, Laurie; Chung, Charles C; Hutchinson, Amy; Yu, Kai; Goh, Chee; Ahmed, Mahbubl; Govindasami, Koveela; Guy, Michelle; Tammela, Teuvo L J; Auvinen, Anssi; Wahlfors, Tiina; Schleutker, Johanna; Visakorpi, Tapio; Leinonen, Katri A; Xu, Jianfeng; Aly, Markus; Donovan, Jenny; Travis, Ruth C; Key, Tim J; Røder, Martin Andreas; Iversen, Peter; Breast and Prostate Cancer Cohort Consortium (BPC3).
I:
Nature Genetics, Bind 46, Nr. 10, 2014, s. 1103-1109.
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Harvard
Al Olama, AA, Kote-Jarai, Z, Berndt, SI, Conti, DV, Schumacher, F, Han, Y, Benlloch, S, Hazelett, DJ, Wang, Z, Saunders, E, Leongamornlert, D, Lindstrom, S, Jugurnauth-Little, S, Dadaev, T, Tymrakiewicz, M, Stram, DO, Rand, K, Wan, P, Stram, A, Sheng, X, Pooler, LC, Park, K, Xia, L, Tyrer, J, Kolonel, LN, Le Marchand, L, Hoover, RN, Machiela, MJ, Yeager, M, Burdette, L, Chung, CC, Hutchinson, A, Yu, K, Goh, C, Ahmed, M, Govindasami, K, Guy, M, Tammela, TLJ, Auvinen, A, Wahlfors, T, Schleutker, J, Visakorpi, T, Leinonen, KA, Xu, J, Aly, M, Donovan, J, Travis, RC, Key, TJ
, Røder, MA, Iversen, P & Breast and Prostate Cancer Cohort Consortium (BPC3) 2014, '
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer',
Nature Genetics, bind 46, nr. 10, s. 1103-1109.
https://doi.org/10.1038/ng.3094APA
Al Olama, A. A., Kote-Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E., Leongamornlert, D., Lindstrom, S., Jugurnauth-Little, S., Dadaev, T., Tymrakiewicz, M., Stram, D. O., Rand, K., Wan, P., Stram, A., ... Breast and Prostate Cancer Cohort Consortium (BPC3) (2014).
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Nature Genetics,
46(10), 1103-1109.
https://doi.org/10.1038/ng.3094Vancouver
Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y o.a.
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Nature Genetics. 2014;46(10):1103-1109.
https://doi.org/10.1038/ng.3094Author
Al Olama, Ali Amin ; Kote-Jarai, Zsofia ; Berndt, Sonja I ; Conti, David V ; Schumacher, Fredrick ; Han, Ying ; Benlloch, Sara ; Hazelett, Dennis J ; Wang, Zhaoming ; Saunders, Ed ; Leongamornlert, Daniel ; Lindstrom, Sara ; Jugurnauth-Little, Sara ; Dadaev, Tokhir ; Tymrakiewicz, Malgorzata ; Stram, Daniel O ; Rand, Kristin ; Wan, Peggy ; Stram, Alex ; Sheng, Xin ; Pooler, Loreall C ; Park, Karen ; Xia, Lucy ; Tyrer, Jonathan ; Kolonel, Laurence N ; Le Marchand, Loic ; Hoover, Robert N ; Machiela, Mitchell J ; Yeager, Merideth ; Burdette, Laurie ; Chung, Charles C ; Hutchinson, Amy ; Yu, Kai ; Goh, Chee ; Ahmed, Mahbubl ; Govindasami, Koveela ; Guy, Michelle ; Tammela, Teuvo L J ; Auvinen, Anssi ; Wahlfors, Tiina ; Schleutker, Johanna ; Visakorpi, Tapio ; Leinonen, Katri A ; Xu, Jianfeng ; Aly, Markus ; Donovan, Jenny ; Travis, Ruth C ; Key, Tim J ; Røder, Martin Andreas ; Iversen, Peter ; Breast and Prostate Cancer Cohort Consortium (BPC3). / A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. I: Nature Genetics. 2014 ; Bind 46, Nr. 10. s. 1103-1109.
Bibtex
@article{af0ad728c5aa46d9954e58046de77d85,
title = "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer",
abstract = "Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.",
keywords = "Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Assessment, Risk Factors",
author = "{Al Olama}, {Ali Amin} and Zsofia Kote-Jarai and Berndt, {Sonja I} and Conti, {David V} and Fredrick Schumacher and Ying Han and Sara Benlloch and Hazelett, {Dennis J} and Zhaoming Wang and Ed Saunders and Daniel Leongamornlert and Sara Lindstrom and Sara Jugurnauth-Little and Tokhir Dadaev and Malgorzata Tymrakiewicz and Stram, {Daniel O} and Kristin Rand and Peggy Wan and Alex Stram and Xin Sheng and Pooler, {Loreall C} and Karen Park and Lucy Xia and Jonathan Tyrer and Kolonel, {Laurence N} and {Le Marchand}, Loic and Hoover, {Robert N} and Machiela, {Mitchell J} and Merideth Yeager and Laurie Burdette and Chung, {Charles C} and Amy Hutchinson and Kai Yu and Chee Goh and Mahbubl Ahmed and Koveela Govindasami and Michelle Guy and Tammela, {Teuvo L J} and Anssi Auvinen and Tiina Wahlfors and Johanna Schleutker and Tapio Visakorpi and Leinonen, {Katri A} and Jianfeng Xu and Markus Aly and Jenny Donovan and Travis, {Ruth C} and Key, {Tim J} and R{\o}der, {Martin Andreas} and Peter Iversen and {Breast and Prostate Cancer Cohort Consortium (BPC3)}",
year = "2014",
doi = "10.1038/ng.3094",
language = "English",
volume = "46",
pages = "1103--1109",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "10",
}
RIS
TY - JOUR
T1 - A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
AU - Al Olama, Ali Amin
AU - Kote-Jarai, Zsofia
AU - Berndt, Sonja I
AU - Conti, David V
AU - Schumacher, Fredrick
AU - Han, Ying
AU - Benlloch, Sara
AU - Hazelett, Dennis J
AU - Wang, Zhaoming
AU - Saunders, Ed
AU - Leongamornlert, Daniel
AU - Lindstrom, Sara
AU - Jugurnauth-Little, Sara
AU - Dadaev, Tokhir
AU - Tymrakiewicz, Malgorzata
AU - Stram, Daniel O
AU - Rand, Kristin
AU - Wan, Peggy
AU - Stram, Alex
AU - Sheng, Xin
AU - Pooler, Loreall C
AU - Park, Karen
AU - Xia, Lucy
AU - Tyrer, Jonathan
AU - Kolonel, Laurence N
AU - Le Marchand, Loic
AU - Hoover, Robert N
AU - Machiela, Mitchell J
AU - Yeager, Merideth
AU - Burdette, Laurie
AU - Chung, Charles C
AU - Hutchinson, Amy
AU - Yu, Kai
AU - Goh, Chee
AU - Ahmed, Mahbubl
AU - Govindasami, Koveela
AU - Guy, Michelle
AU - Tammela, Teuvo L J
AU - Auvinen, Anssi
AU - Wahlfors, Tiina
AU - Schleutker, Johanna
AU - Visakorpi, Tapio
AU - Leinonen, Katri A
AU - Xu, Jianfeng
AU - Aly, Markus
AU - Donovan, Jenny
AU - Travis, Ruth C
AU - Key, Tim J
AU - Røder, Martin Andreas
AU - Iversen, Peter
AU - Breast and Prostate Cancer Cohort Consortium (BPC3)
PY - 2014
Y1 - 2014
N2 - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
AB - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Prostatic Neoplasms
KW - Risk Assessment
KW - Risk Factors
U2 - 10.1038/ng.3094
DO - 10.1038/ng.3094
M3 - Letter
C2 - 25217961
VL - 46
SP - 1103
EP - 1109
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -
