A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities
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A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities. / Bhuiyan, Tanveer A; Graff, Claus; Kanters, Jørgen K; Melgaard, Jacob; Toft, Egon; Kääb, Stefan; Struijk, Johannes J.
I: Clinical Pharmacology and Therapeutics, Bind 103, Nr. 6, 2018, s. 1100-1106.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities
AU - Bhuiyan, Tanveer A
AU - Graff, Claus
AU - Kanters, Jørgen K
AU - Melgaard, Jacob
AU - Toft, Egon
AU - Kääb, Stefan
AU - Struijk, Johannes J
N1 - © 2017 American Society for Clinical Pharmacology and Therapeutics.
PY - 2018
Y1 - 2018
N2 - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.
AB - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.
UR - http://www.scopus.com/inward/record.url?scp=85032187887&partnerID=8YFLogxK
U2 - 10.1002/cpt.886
DO - 10.1002/cpt.886
M3 - Journal article
C2 - 28940299
VL - 103
SP - 1100
EP - 1106
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 6
ER -
ID: 189664609