1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice.

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Standard

1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice. / Troelsen, J T; Mehlum, A; Spodsberg, N; Prydz, H; Norén, O; Sjöström, H; Olsen, Jørgen; Hansen, Gert Helge.

I: FEBS Letters, Bind 342, Nr. 3, 1994, s. 291-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Troelsen, JT, Mehlum, A, Spodsberg, N, Prydz, H, Norén, O, Sjöström, H, Olsen, J & Hansen, GH 1994, '1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice.', FEBS Letters, bind 342, nr. 3, s. 291-6. https://doi.org/10.1016/0014-5793(94)80519-9

APA

Troelsen, J. T., Mehlum, A., Spodsberg, N., Prydz, H., Norén, O., Sjöström, H., Olsen, J., & Hansen, G. H. (1994). 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice. FEBS Letters, 342(3), 291-6. https://doi.org/10.1016/0014-5793(94)80519-9

Vancouver

Troelsen JT, Mehlum A, Spodsberg N, Prydz H, Norén O, Sjöström H o.a. 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice. FEBS Letters. 1994;342(3):291-6. https://doi.org/10.1016/0014-5793(94)80519-9

Author

Troelsen, J T ; Mehlum, A ; Spodsberg, N ; Prydz, H ; Norén, O ; Sjöström, H ; Olsen, Jørgen ; Hansen, Gert Helge. / 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice. I: FEBS Letters. 1994 ; Bind 342, Nr. 3. s. 291-6.

Bibtex

@article{d599fb809a8111dd86a6000ea68e967b,
title = "1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice.",
abstract = "Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch -17 to -994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit beta-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.",
author = "Troelsen, {J T} and A Mehlum and N Spodsberg and H Prydz and O Nor{\'e}n and H Sj{\"o}str{\"o}m and J{\o}rgen Olsen and Hansen, {Gert Helge}",
note = "Keywords: Age Factors; Animals; Gene Expression Regulation; Glycosylceramidase; Intestine, Small; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Promoter Regions (Genetics); RNA, Messenger; Tissue Distribution; Transcription, Genetic",
year = "1994",
doi = "10.1016/0014-5793(94)80519-9",
language = "English",
volume = "342",
pages = "291--6",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice.

AU - Troelsen, J T

AU - Mehlum, A

AU - Spodsberg, N

AU - Prydz, H

AU - Norén, O

AU - Sjöström, H

AU - Olsen, Jørgen

AU - Hansen, Gert Helge

N1 - Keywords: Age Factors; Animals; Gene Expression Regulation; Glycosylceramidase; Intestine, Small; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Promoter Regions (Genetics); RNA, Messenger; Tissue Distribution; Transcription, Genetic

PY - 1994

Y1 - 1994

N2 - Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch -17 to -994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit beta-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.

AB - Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch -17 to -994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit beta-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.

U2 - 10.1016/0014-5793(94)80519-9

DO - 10.1016/0014-5793(94)80519-9

M3 - Journal article

C2 - 8150087

VL - 342

SP - 291

EP - 296

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 3

ER -

ID: 6604904