β Cell and Autophagy: What Do We Know?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.
Originalsprog | Engelsk |
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Artikelnummer | 649 |
Tidsskrift | Biomolecules |
Vol/bind | 13 |
Udgave nummer | 4 |
ISSN | 2218-273X |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The Lundbeck foundation grants R303-2018-3148 and the Stanford Maternal and Child Health Research Institute (MCHRI).
Publisher Copyright:
© 2023 by the authors.
ID: 346594972