β Cell and Autophagy: What Do We Know?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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β Cell and Autophagy : What Do We Know? / Mohammadi-Motlagh, Hamid Reza; Sadeghalvad, Mona; Yavari, Niloofar; Primavera, Rosita; Soltani, Setareh; Chetty, Shashank; Ganguly, Abantika; Regmi, Shobha; Fløyel, Tina; Kaur, Simranjeet; Mirza, Aashiq H.; Thakor, Avnesh S.; Pociot, Flemming; Yarani, Reza.
I: Biomolecules, Bind 13, Nr. 4, 649, 2023.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - β Cell and Autophagy
T2 - What Do We Know?
AU - Mohammadi-Motlagh, Hamid Reza
AU - Sadeghalvad, Mona
AU - Yavari, Niloofar
AU - Primavera, Rosita
AU - Soltani, Setareh
AU - Chetty, Shashank
AU - Ganguly, Abantika
AU - Regmi, Shobha
AU - Fløyel, Tina
AU - Kaur, Simranjeet
AU - Mirza, Aashiq H.
AU - Thakor, Avnesh S.
AU - Pociot, Flemming
AU - Yarani, Reza
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.
AB - Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.
KW - autophagy
KW - autophagy modulators
KW - insulin homeostasis
KW - type 1 diabetes
KW - type 2 diabetes
KW - β cell
U2 - 10.3390/biom13040649
DO - 10.3390/biom13040649
M3 - Review
C2 - 37189396
AN - SCOPUS:85156131239
VL - 13
JO - Biomolecules
JF - Biomolecules
SN - 2218-273X
IS - 4
M1 - 649
ER -
ID: 346594972