β Cell and Autophagy

β Cell and Autophagy: What Do We Know?

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

β Cell and Autophagy : What Do We Know? / Mohammadi-Motlagh, Hamid Reza; Sadeghalvad, Mona; Yavari, Niloofar; Primavera, Rosita; Soltani, Setareh; Chetty, Shashank; Ganguly, Abantika; Regmi, Shobha; Fløyel, Tina; Kaur, Simranjeet; Mirza, Aashiq H.; Thakor, Avnesh S.; Pociot, Flemming; Yarani, Reza.

I: Biomolecules, Bind 13, Nr. 4, 649, 2023.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Mohammadi-Motlagh, HR, Sadeghalvad, M, Yavari, N, Primavera, R, Soltani, S, Chetty, S, Ganguly, A, Regmi, S, Fløyel, T, Kaur, S, Mirza, AH, Thakor, AS, Pociot, F & Yarani, R 2023, 'β Cell and Autophagy: What Do We Know?', Biomolecules, bind 13, nr. 4, 649. https://doi.org/10.3390/biom13040649

APA

Mohammadi-Motlagh, H. R., Sadeghalvad, M., Yavari, N., Primavera, R., Soltani, S., Chetty, S., Ganguly, A., Regmi, S., Fløyel, T., Kaur, S., Mirza, A. H., Thakor, A. S., Pociot, F., & Yarani, R. (2023). β Cell and Autophagy: What Do We Know? Biomolecules, 13(4), [649]. https://doi.org/10.3390/biom13040649

Vancouver

Mohammadi-Motlagh HR, Sadeghalvad M, Yavari N, Primavera R, Soltani S, Chetty S o.a. β Cell and Autophagy: What Do We Know? Biomolecules. 2023;13(4). 649. https://doi.org/10.3390/biom13040649

Author

Mohammadi-Motlagh, Hamid Reza ; Sadeghalvad, Mona ; Yavari, Niloofar ; Primavera, Rosita ; Soltani, Setareh ; Chetty, Shashank ; Ganguly, Abantika ; Regmi, Shobha ; Fløyel, Tina ; Kaur, Simranjeet ; Mirza, Aashiq H. ; Thakor, Avnesh S. ; Pociot, Flemming ; Yarani, Reza. / β Cell and Autophagy : What Do We Know?. I: Biomolecules. 2023 ; Bind 13, Nr. 4.

Bibtex

@article{03f4fbe64c8d474bbd6b351d6d4d6133,

title = "β Cell and Autophagy: What Do We Know?",

abstract = "Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells{\textquoteright} fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.",

keywords = "autophagy, autophagy modulators, insulin homeostasis, type 1 diabetes, type 2 diabetes, β cell",

author = "Mohammadi-Motlagh, {Hamid Reza} and Mona Sadeghalvad and Niloofar Yavari and Rosita Primavera and Setareh Soltani and Shashank Chetty and Abantika Ganguly and Shobha Regmi and Tina Fl{\o}yel and Simranjeet Kaur and Mirza, {Aashiq H.} and Thakor, {Avnesh S.} and Flemming Pociot and Reza Yarani",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

doi = "10.3390/biom13040649",

language = "English",

volume = "13",

journal = "Biomolecules",

issn = "2218-273X",

publisher = "MDPI",

number = "4",

}

RIS

TY - JOUR

T1 - β Cell and Autophagy

T2 - What Do We Know?

AU - Mohammadi-Motlagh, Hamid Reza

AU - Sadeghalvad, Mona

AU - Yavari, Niloofar

AU - Primavera, Rosita

AU - Soltani, Setareh

AU - Chetty, Shashank

AU - Ganguly, Abantika

AU - Regmi, Shobha

AU - Fløyel, Tina

AU - Kaur, Simranjeet

AU - Mirza, Aashiq H.

AU - Thakor, Avnesh S.

AU - Pociot, Flemming

AU - Yarani, Reza

PY - 2023

Y1 - 2023

N2 - Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.

AB - Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure.

KW - autophagy

KW - autophagy modulators

KW - insulin homeostasis

KW - type 1 diabetes

KW - type 2 diabetes

KW - β cell

U2 - 10.3390/biom13040649

DO - 10.3390/biom13040649

M3 - Review

C2 - 37189396

AN - SCOPUS:85156131239

VL - 13

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 4

M1 - 649

ER -

ID: 346594972