€ Barrier dysfunction in Atopic newBorns studY' (BABY): Protocol of a Danish prospective birth cohort study
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€ Barrier dysfunction in Atopic newBorns studY' (BABY) : Protocol of a Danish prospective birth cohort study. / Gerner, Trine; Halling, Anne Sofie; Rasmussen Rinnov, Maria; Haarup Ravn, Nina; Hjorslev Knudgaard, Mette; Menné Bonefeld, Charlotte; Ewertsen, Caroline; Trautner, Simon; Jakaša, Ivone; Kezic, Sanja; Skov, Lone; Thyssen, Jacob P.
I: BMJ Open, Bind 10, Nr. 7, e033801, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - € Barrier dysfunction in Atopic newBorns studY' (BABY)
T2 - Protocol of a Danish prospective birth cohort study
AU - Gerner, Trine
AU - Halling, Anne Sofie
AU - Rasmussen Rinnov, Maria
AU - Haarup Ravn, Nina
AU - Hjorslev Knudgaard, Mette
AU - Menné Bonefeld, Charlotte
AU - Ewertsen, Caroline
AU - Trautner, Simon
AU - Jakaša, Ivone
AU - Kezic, Sanja
AU - Skov, Lone
AU - Thyssen, Jacob P.
PY - 2020
Y1 - 2020
N2 - Introduction Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD). Methods and analysis The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age (GA) below 37+0) and 300 term children (GA 37+0 to 41+6). Skin barrier is assessed through transepidermal water loss, tape stripping, Raman-spectroscopy and microbiome sampling. Clinical examinations are done and DNA from buccal swabs is collected for genetic analyses. Thymus size is assessed by ultrasound examination. Information on pregnancy, delivery, parental exposures and diseases are collected, and structured telephone interviews are conducted at 18 and 24 months to assess exogenous exposures in the child and onset of AD. Hanifin and Rajka criteria as well as The UK Working Party's Diagnostic Criteria for Atopic Dermatitis are used to diagnose AD. Severity of AD is assessed using the Eczema Area and Severity Index (EASI) and Patient Oriented Eczema Measure (POEM). Ethics and dissemination The study is approved by the scientific Ethical Committee of the Capital Region (H-16042289 and H-16042294). Outcomes will be presented at national and international conferences and in peer-reviewed publications.
AB - Introduction Skin barrier development and dysfunction in premature and mature newborns is important for the risk of atopic dermatitis (AD). Methods and analysis The Barrier dysfunction in Atopic newBorns studY (BABY) Cohort is a prospective birth cohort study of 150 preterm children (gestational age (GA) below 37+0) and 300 term children (GA 37+0 to 41+6). Skin barrier is assessed through transepidermal water loss, tape stripping, Raman-spectroscopy and microbiome sampling. Clinical examinations are done and DNA from buccal swabs is collected for genetic analyses. Thymus size is assessed by ultrasound examination. Information on pregnancy, delivery, parental exposures and diseases are collected, and structured telephone interviews are conducted at 18 and 24 months to assess exogenous exposures in the child and onset of AD. Hanifin and Rajka criteria as well as The UK Working Party's Diagnostic Criteria for Atopic Dermatitis are used to diagnose AD. Severity of AD is assessed using the Eczema Area and Severity Index (EASI) and Patient Oriented Eczema Measure (POEM). Ethics and dissemination The study is approved by the scientific Ethical Committee of the Capital Region (H-16042289 and H-16042294). Outcomes will be presented at national and international conferences and in peer-reviewed publications.
KW - atopic dermatitis
KW - birth cohort
KW - preterm
KW - Raman
KW - skin barrier
KW - TEWL
U2 - 10.1136/bmjopen-2019-033801
DO - 10.1136/bmjopen-2019-033801
M3 - Journal article
C2 - 32660946
AN - SCOPUS:85088030888
VL - 10
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 7
M1 - e033801
ER -
ID: 247689764