Niels Grarup
Lektor
Grarup Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
Aktuel forskning
Type 2 diabetes is a disorder caused by a subtle combination of heritable factors and environmental and lifestyle risk factors. Also intermediary diabetes-related physiological traits such as obesity, insulin resistance and disturbed insulin secretion have been shown to be partly modulated by genetic factors. My research interests are focused on identification genetic variation associated with type 2 diabetes (diabetes genomics discovery) and on performing detailed physiological characterization of these variants in relation to diabetes phenotype (genetic-epidemiology and genetic-physiology studies). Genetic variation is explored by both next generation nucleotide sequencing and by large-scale genotyping array-based genotyping. The long term goals are to gain a deeper understanding of the genetic architecture of type 2 diabetes, to expand our insights into diabetes pathogenesis and pathophysiology and possibly thereby derive novel drug targets for diabetes and in the longer term cause advances in clinical diabetes management and prevention.
Udvalgte publikationer
- Udgivet
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Moltke, Ida, Grarup, Niels, Jørgensen, M. E., Bjerregaard, P., Treebak, Jonas Thue, Fumagalli, M., Korneliussen, Thorfinn Sand, Andersen, M. A., Nielsen, Thomas Svava, Krarup, N. T., Gjesing, A. M. P., Zierath, Juleen R, Linneberg, Allan René, Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, Oluf Borbye, Nielsen, R., Albrechtsen, Anders & Hansen, Torben, 2014, I: Nature. 512, 7513, s. 190-193 4 s.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
ID: 10892605
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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5182
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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2421
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Estimation of allele frequency and association mapping using next-generation sequencing data
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet