Lars Ellgaard

Lars Ellgaard

Professor

ORCID: 0000-0002-7018-0137

Publication year:
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  1. 1994

  2. Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of Mr 40,000 receptor associated protein

    Simonsen, A. C. W., Heegaard, C. W., Rasmussen, L. K., Ellgaard, Lars, Kjøller, L., Christensen, A., Etzerodt, M. & Andreasen, P. A., 1994, In: FEBS Letters. 354, 3, p. 279-283

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 1995

  4. Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of α2-macroglobulin receptor and urokinase receptor expression

    Kjøller, L., Simonsen, A. C. W., Ellgaard, Lars & Andreasen, P. A., 1995, In: Molecular and Cellular Endocrinology. 109, 2, p. 209-217

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein

    Ellgaard, Lars, Holtet, T. L., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C., 1995, In: Journal of Immunological Methods. 180, 1, p. 53-61

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex

    Heegaard, C. W., Simonsen, A. C. W., Oka, K., Kjøller, L., Christensen, A., Madsen, B., Ellgaard, Lars, Chan, L. & Andreasen, P. A., 1995, In: Journal of Biological Chemistry. 270, 35, p. 20855-20861

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 1996

  8. The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II

    Petersen, C. M., Ellgaard, Lars, Nykjaer, A., Vilhardt, F., Vorum, H., Thøgersen, H. C., Nielsen, M. S., Jacobsen, C., Moestrup, S. K. & Gliemann, J., 1996, In: EMBO Journal. 15, 16, p. 4165-4173

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1997

  10. Dissection of the Domain Architecture of the α2macroglobulin-Receptor-Associated Protein

    Ellgaard, Lars, Holtet, T. L., Nielsen, P. R., Etzerodt, M., Gliemann, J. & Thøgersen, H. C., 1997, In: European Journal of Biochemistry. 244, 2, p. 544-551

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. The solution structure of the N-terminal domain of α2-macroglobnlin receptor-associated protein

    Nielsen, P. R., Ellgaard, Lars, Etzerodt, M., Thøgersen, H. C. & Poulsen, F. M., 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 14, p. 7521-7525

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 1998

  13. The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

    Tauris, J., Ellgaard, Lars, Jacobsen, C., Nielsen, M. S., Madsen, P., Thøgersen, H. C., Gliemann, J., Petersen, C. M. & Moestrup, S. K., 1998, In: FEBS Letters. 429, 1, p. 27-30

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 1999

  15. Ligand Binding Properties of the Very Low Density Lipoprotein Receptor: ABSENCE OF THE THIRD COMPLEMENT-TYPE REPEAT ENCODED BY EXON 4 IS ASSOCIATED WITH REDUCED BINDING OF M r 40,000 RECEPTOR-ASSOCIATED PROTEIN

    Rettenberger, P. M., Oka, K., Ellgaard, Lars, Petersen, H. H., Christensen, A., Martensen, P. M., Monard, D., Etzerodt, M., Chan, L. & Andreasen, P. A., 1999, In: Journal of Biological Chemistry. 274, 13, p. 8973-8980

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Localization of a Single Transglutaminase-Reactive Glutamine in the Third Domain of RAP, the α2-Macroglobulin Receptor-Associated Protein

    Rasmussen, L. K., Ellgaard, Lars, Jensen, P. H. & Sørensen, E. S., 1999, In: Journal of Protein Chemistry. 18, 1, p. 69-73

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Setting the Standards: Quality Control in the Secretory Pathway

    Ellgaard, Lars, Molinari, M. & Helenius, A., 1999, In: Science. 286, 5446, p. 1882-1888

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2001

  19. ER quality control: towards an understanding at the molecular level

    Ellgaard, Lars & Helenius, A., 2001, In: Current Opinion in Cell Biology. 13, 4, p. 431-437

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. NMR structure of the calreticulin P-domain

    Ellgaard, Lars, Riek, R., Herrmann, T., Güntert, P., Braun, D., Helenius, A. & Wüthrich, K., 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 6, p. 3133-3138

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Three-dimensional structure topology of the calreticulin P-domain based on NMR assignment

    Ellgaard, Lars, Riek, R., Braun, D., Herrmann, T., Helenius, A. & Wüthrich, K., 2001, In: FEBS Letters. 488, 1-2, p. 69-73

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2002

  23. NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain

    Ellgaard, Lars, Bettendorff, P., Braun, D., Herrmann, T., Fiorito, F., Jelesarov, I., Güntert, P., Helenius, A. & Wüthrich, K., 2002, In: Journal of Molecular Biology. 322, 4, p. 773-784

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain

    Frickel, E., Riek, R., Jelesarov, I., Helenius, A., Wüthrich, K. & Ellgaard, Lars, 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 1954-1959

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2003

  26. Calnexin, calreticulin, and ERp57: Teammates in glycoprotein folding

    Ellgaard, Lars & Frickel, E., 2003, In: Cell Biochemistry and Biophysics. 39, 3, p. 223-247

    Research output: Contribution to journal › Review › Research › peer-review

  27. Interactions of Substrate with Calreticulin, an Endoplasmic Reticulum Chaperone

    Kapoor, M., Srinivas, H., Kandiah, E., Gemma, E., Ellgaard, Lars, Oscarson, S., Helenius, A. & Surolia, A., 2003, In: Journal of Biological Chemistry. 278, 8, p. 6194-6200

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. 2004

  29. Catalysis of disulphide bond formation in the endoplasmic reticulum

    Ellgaard, Lars, 2004, In: Biochemical Society Transactions. 32, 5, p. 663-667

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase

    Frickel, E., Frei, P., Bouvier, M., Stafford, W. F., Helenius, A., Glockshuber, R. & Ellgaard, Lars, 2004, In: Journal of Biological Chemistry. 279, 18, p. 18277-18287

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Mutational Analysis Provides Molecular Insight into the Carbohydrate-Binding Region of Calreticulin: Pivotal Roles of Tyrosine-109 and Aspartate-135 in Carbohydrate Recognition

    Kapoor, M., Ellgaard, Lars, Gopalakrishnapai, J., Schirra, C., Gemma, E., Oscarson, S., Helenius, A. & Surolia, A., 2004, In: Biochemistry. 43, 1, p. 97-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2005

  33. The human protein disulphide isomerase family: substrate interactions and functional properties

    Ellgaard, Lars & Ruddock, L. W., 2005, In: EMBO Reports. 6, 1, p. 28-32

    Research output: Contribution to journal › Review › Research › peer-review

  34. 2006
  35. Published

    Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

    Kulp, M. S., Frickel, E. M., Ellgaard, Lars & Weismann, J. S., 2006, In: Journal of Biological Chemistry. 281, 2, p. 876-84.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2007
  37. Published

    Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells.

    Schelhaas, M., Malmström, J., Pelkmans, L., Haugstetter, J., Ellgaard, Lars, Grünewald, K. & Helenius, A., 2007, In: Cell. 131, 3, p. 516-29 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Structure-Function Analysis of the Endoplasmic Reticulum Oxidoreductase TMX3 Reveals Interdomain Stabilization of the N-terminal Redox-active Domain

    Haugstetter, J., Maurer, M. A., Blicher, T., Pagac, M., Wider, G. & Ellgaard, Lars, 2007, In: Journal of Biological Chemistry. 282, 46, p. 33859-33867

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Structure-function analysis of the ER oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain

    Haugstetter, J., Michael, M., Blicher, T., Pagac, M., Wider, G. & Ellgaard, Lars, 2007, In: Journal of Biological Chemistry. 280, 46, p. 33859-33867

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The human PDI family: Versatility packed into a single fold.

    Ellgaard, Lars & Ellgaard, Lars, 2007, In: BBA General Subjects.

    Research output: Contribution to journal › Review › Research › peer-review

  41. 2008
  42. Published

    A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells

    Appenzeller-Herzog, C., Riemer, J., Christensen, B., Sørensen, E. B. & Ellgaard, Lars, 2008, In: EMBO Journal. 27, p. 2977–2987

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

    Appenzeller-Herzog, C., Riemer, J., Christensen, B., Sørensen, E. S. & Ellgaard, Lars, 2008, In: EMBO Journal. 27, 22, p. 2977-2987

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms

    Appenzeller-Herzog, C. & Ellgaard, Lars, 2008, In: Antioxidants & Redox Signaling. 10, 1, p. 55-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. 2009
  46. Published

    A luminal flavoprotein in endoplasmic reticulum-associated degradation

    Riemer, J., Appenzeller-Herzog, C., Johansson, L., Bodenmiller, B., Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 35, p. 14831-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2010
  48. Published

    A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

    Roth, D., Lynes, E., Riemer, J., Hansen, H. G., Althaus, N., Simmen, T. & Ellgaard, Lars, 2010, In: Biochemical Journal. 425, 1, p. 195-205 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    A male with unilateral microphthalmia reveals a role for TMX3 in eye development

    Chao, R., Nevin, L., Agarwal, P., Riemer, J., Bai, X., Delaney, A., Akana, M., JimenezLopez, N., Bardakjian, T., Schneider, A., Chassaing, N., Schorderet, D. F., FitzPatrick, D., Kwok, P., Ellgaard, Lars, Gould, D. B., Zhang, Y., Malicki, J., Baier, H. & Slavotinek, A., 2010, In: PLoS ONE. 5, 5, p. e10565 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Disulphide production by Ero1α-PDI relay is rapid and effectively regulated

    Appenzeller-Herzog, C., Riemer, J., Zito, E., Chin, K., Ron, D., Spiess, M. & Ellgaard, Lars, 2010, In: EMBO Journal. 29, 19, p. 3318-3329

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Disulphide production by Ero1a-PDI relay is rapid and effectively regulated

    Appenzeller-Herzog, C., Riemer, J., Zito, E., Chin, K., Ron, D., Spiess, M. & Ellgaard, Lars, 6 Oct 2010, In: EMBO Journal. 29, 19, p. 3318-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2011
  53. Published

    Identification of the PDI-family member ERp90 as an interaction partner of ERFAD

    Riemer, J., Hansen, H. G., Appenzeller-Herzog, C., Appenzeller-Herzog, C., Johansson, L. & Ellgaard, Lars, 2011, In: P L o S One. 6, 2, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Multiple ways to make disulfides

    Bulleid, N. J. & Ellgaard, Lars, 2011, In: Trends in Biochemical Sciences. 36, 9, p. 485-92 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2012
  56. Published

    HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin

    Poulsen, E. G., Steinhauer, C., Lees, M., Lauridsen, A., Ellgaard, Lars & Hartmann-Petersen, Rasmus, 2012, In: P L o S One. 7, 11, 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response

    Hansen, H. G., Schmidt, J. D., Søltoft, C. L., Ramming, T., Geertz-Hansen, H. M., Christensen, B., Sørensen, E. S., Juncker, A., Appenzeller, C. A. & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 47, p. 39513-39523 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

    Kriegenburg, F., Ellgaard, Lars & Hartmann-Petersen, Rasmus, 2012, In: F E B S Journal. 279, 4, p. 532-542 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

    Lynes, E. M., Bui, M., Yap, M. C., Benson, M. D., Schneider, B., Ellgaard, Lars, Berthiaume, L. G. & Simmen, T., 2012, In: E M B O Journal. 31, 2, p. 457-470 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

    Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. 2014
  62. Published

    Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

    Hansen, H. G., Søltoft, C. L., Schmidt, J. D., Birk, J., Appenzeller-Herzog, C. & Ellgaard, Lars, 2014, In: Bioscience Reports. 34, 2, 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

    Ramming, T., Hansen, H. G., Nagata, K., Ellgaard, Lars & Appenzeller-Herzog, C., 2014, In: Free Radical Biology & Medicine. 70, p. 106-116 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Giftsnegle som medicinskabe

    Safavi, Helena, Andersen, K. M. & Ellgaard, Lars, 2014, In: Aktuel Naturvidenskab. 2014, 2, p. 12-16 5 p.

    Research output: Contribution to journal › Journal article › Research

  65. Published

    The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D

    Hagemann-Jensen, M. H., Uhlenbrock, F. K., Kehlet, S., Andresen, Lars, Gabel-Jensen, C., Ellgaard, Lars, Gammelgaard, Bente & Skov, Søren, 2014, In: The Journal of Biological Chemistry. 289, p. 31576-31590 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. 2015
  67. Published

    Specialized insulin is used for chemical warfare by fish-hunting cone snails

    Safavi, Helena, Gajewiak, J., Karanth, S., Robinson, S. D., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, Lars & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743-1748 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2016
  69. Published

    Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

    Timms, R. T., Menzies, S. A., Tchasovnikarova, I. A., Christensen, L. C., Williamson, J. C., Antrobus, R., Dougan, G., Ellgaard, Lars & Lehner, P. J., 2016, In: Nature Communications. 7, 10 p., 11786.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

    Safavi, Helena, Li, Q., Jackson, R. L., Song, A. S., Boomsma, Wouter, Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, Lars, 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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