René Villadsen
Associate Professor
Morphogenesis and Differentiation Program
Blegdamsvej 3
2200 København N.
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Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus
Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Villadsen, René & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 44.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer
Bagger, M. M., Sjölund, J., Kim, Jiyoung, Kohler, Katharina Theresa, Villadsen, René, Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Pietras, K., Rønnov-Jessen, Lone & Petersen, Ole William, 2024, In: Breast Cancer Research. 26, 1, 19 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
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Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity
Bagger, Sofie Morsing, Hopkinson, B. M., Pandey, D. P., Bak, M., Brydholm, A. V., Villadsen, René, Helin, K., Rønnov-Jessen, Lone, Petersen, Ole William & Kim, Jiyoung, 2018, In: Molecular Cancer. 17, 1, p. 1-6 6 p., 171.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A Marker of Endocrine Receptor-Positive Cells, CEACAM6, Is Shared by Two Major Classes of Breast Cancer: Luminal and HER2-Enriched
Balk-Møller, E., Kim, Jiyoung, Hopkinson, B., Timmermans-Wielenga, V., Petersen, Ole William & Villadsen, René, Apr 2014, In: American Journal of Pathology. 184, 4, p. 1198-1208 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterogeneity of CEACAM5 in breast cancer
Bechmann, M. B., Brydholm, A. V., Codony, V. L., Kim, Jiyoung & Villadsen, René, 2020, In: OncoTarget. 11, 43, p. 3886-3899 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genesers Histologi
Brüel, A., Christensen, E. I., Eld, M., Prætorius, J., Qvortrup, Klaus, Tranum-Jensen, Jørgen, Villadsen, René & Geneser, F., 2020, 2 ed. Danmark: Munksgaard . 741 p.Research output: Book/Report › Book › Education
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Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment
De Neergaard, M., Kim, Jiyoung, Villadsen, René, Fridriksdóttir, A. J. R., Rank, F., Timmermans-Wielenga, V., Langerød, A., Børresen-Dale, A., Petersen, Ole William & Rønnov-Jessen, Lone, 2010, In: American Journal of Pathology. 176, 3, p. 1229-1240 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer
Eichenlaub, T., Villadsen, René, Freitas, F. C. P., Andrejeva, Diana, Aldana, Blanca, Nguyen, H. T., Petersen, Ole William, Gorodkin, Jan, Herranz, Hector & Cohen, S. M., 2018, In: Current Biology. 28, 20, p. 3220-3228.e6Research output: Contribution to journal › Journal article › Research › peer-review
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AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer
Engelsen, A. S. T., Wnuk-Lipinska, K., Bougnaud, S., Pelissier Vatter, F. A., Tiron, C., Villadsen, R., Miyano, M., Lotsberg, M. L., Madeleine, N., Panahandeh, P., Dhakal, S., Tan, T. Z., Peters, S. D. M., Grøndal, S., Aziz, S. M., Nord, S., Herfindal, L., Stampfer, M. R., Sørlie, T., Brekken, R. A. & 8 others, , 2020, In: iScience. 23, 11, 40 p., 101649.Research output: Contribution to journal › Journal article › Research › peer-review
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Proof of region-specific multipotent progenitors in human breast epithelia
Fridriksdottir, A. J., Villadsen, René, Morsing, M., Klitgaard, M. C., Kim, Jiyoung, Petersen, Ole William & Rønnov-Jessen, Lone, 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. E10102–E10111Research output: Contribution to journal › Journal article › Research › peer-review
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Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture
Fridriksdóttir, A. J. R., Kim, Jiyoung, Villadsen, René, Klitgaard, M. C., Hopkinson, B. M., Petersen, Ole William & Rønnov-Jessen, Lone, 2015, In: Nature Communications. 6, 12 p., 8786.Research output: Contribution to journal › Journal article › Research › peer-review
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Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia
Garbe, J. C., Pepin, F., Pelissier, F. A., Sputova, K., Fridriksdottir, A. J., Guo, D. E., Villadsen, René, Park, M., Petersen, Ole William, Borowsky, A. D., Stampfer, M. R. & Labarge, M. A., Jul 2012, In: Cancer Research. 72, 14, p. 3687-701 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation
Goldhammer, N., Kim, Jiyoung, Villadsen, René, Rønnov-Jessen, Lone & Petersen, Ole William, 2022, In: Communications Biology . 5, 1, 13 p., 219.Research output: Contribution to journal › Journal article › Research › peer-review
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Immortalization protocols used in cell culture models of human breast morphogenesis
Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Petersen, O. W., 2004, In: Cellular and molecular life sciences : CMLS. 61, 19-20, p. 2523-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties
Gudjonsson, T., Villadsen, René, Nielsen, H. L., Rønnov-Jessen, Lone, Bissell, M. J. & Petersen, Ole William, 2002, In: Genes Dev. vol. 16(6), p. 693-706Research output: Contribution to journal › Journal article › Research › peer-review
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Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
Gudjonsson, T., Rønnov-Jessen, Lone, Villadsen, René, Rank, F. E., Bissell, M. J. & Petersen, Ole William, 2002, In: Journal of Cell Science. 115, p. 39-50Research output: Contribution to journal › Journal article › Research › peer-review
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To create the correct microenvironment: Three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia
Gudjonsson, T., Rønnov-Jessen, Lone, Villadsen, René, Bissell, M. J. & Petersen, Ole William, 2003, In: Methods. Vol. 30, p. 247-255Research output: Contribution to journal › Journal article › Research › peer-review
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Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype
Hopkinson, B. M., Klitgaard, M. C., Petersen, Ole William, Villadsen, René, Rønnov-Jessen, Lone & Kim, Jiyoung, 7 Feb 2017, In: OncoTarget. 8, 6, p. 10580-10593 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland
Kim, Jiyoung & Villadsen, René, Dec 2018, In: Journal of Histochemistry and Cytochemistry. 66, 12, p. 879-888 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
Kim, Jiyoung, Villadsen, René, Sørlie, T., Fogh, L., Grønlund, S. Z., Fridriksdóttir, A. J. R., Kuhn, I., Rank, F., Wielenga, V. T., Solvang, H., Edwards, P. A. W., Børresen-Dale, A., Rønnov-Jessen, Lone, Bissell, M. J. & Petersen, Ole William, 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6124-6129 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Expression Pattern of Epidermal Differentiation Marker Keratin 10 in the Normal Human Breast and Breast Cancer Cells
Kim, Jiyoung & Villadsen, René, 2020, In: Journal of Histochemistry and Cytochemistry. 68, 8, p. 561-570Research output: Contribution to journal › Journal article › Research › peer-review
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SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer
Kohler, Katharina Theresa, Møller Hansen, A. A., Kim, Jiyoung & Villadsen, René, 2023, In: Journal of Histochemistry and Cytochemistry. 71, 8, 221554231189312.Research output: Contribution to journal › Journal article › Research › peer-review
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Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature
Kohler, Katharina Theresa, Goldhammer, N., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Rønnov-Jessen, Lone, Petersen, Ole William, Villadsen, René & Kim, Jiyoung, 2022, In: npj Breast Cancer. 8, 1, 12 p., 81.Research output: Contribution to journal › Journal article › Research › peer-review
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Human mammary progenitor cell fate decisions are productsof interactions with combinatorial microenvironments
LaBarge, M. A., Nelson, C. M., Villadsen, René, Rubner Fridriksdottir, A. J., Ruth, J. R., Stampfer, M. R., Petersen, Ole William & Bissell, M. J., 2009, In: Integrative Biology. 1, p. 70-79 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence of two distinct functionally specialized fibroblast lineages in breast stroma
Morsing, M., Klitgaard, M. C., Jafari Kermani, Abbas, Villadsen, René, Kassem, Moustapha Saad El-Deen, Petersen, Ole William & Rønnov-Jessen, Lone, 2016, In: Breast Cancer Research (Online). 18, 11 p., 108.Research output: Contribution to journal › Journal article › Research › peer-review
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Fibroblasts direct differentiation of human breast epithelial progenitors
Morsing, M., Kim, Jiyoung, Villadsen, René, Goldhammer, N., Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Petersen, Ole William & Rønnov-Jessen, Lone, 2020, In: Breast Cancer Research. 22, 16 p., 102.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer
Nielsen, H. L., Rønnov-Jessen, Lone, Villadsen, René & Petersen, Ole William, 2002, In: Genomics. 79, 5, p. 703-10 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression
Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Petersen, Ole William, 2004, In: In Vitro Cellular & Developmental Biology - Animal. 39, 7, p. 297-303 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma
Petersen, Ole William, Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rank, F. E., Niebuhr, E., Bisell, M. J. & Rønnov-Jessen, Lone, 2003, In: American Journal og Pathology. Vol. 162, p. 391-402Research output: Contribution to journal › Journal article › Research › peer-review
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Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia
Petersen, Ole William, Gudjonsson, T., Villadsen, René, Bissell, M. J. & Rønnov-Jessen, Lone, 2003, In: Cell Proliferation. 36 Suppl 1, p. 33-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion
Petersen, Ole William, Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Bissell, M. J., 2001, In: Breast Cancer Research (Online Edition). 3, p. 213-217Research output: Contribution to journal › Review › Research
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Maintenance of Cell Type Diversification in the Human Breast
Rubner Fridriksdottir, A. J., Villadsen, René, Gudjonsson, T. & Petersen, Ole William, 2005, In: Journal of Mammary Gland Biology and Neoplasia. 10, 1, p. 61-74Research output: Contribution to journal › Journal article › Research › peer-review
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Dissection of a stem cell hierarchy in the human breast
Rubner Fridriksdottir, A. J., Villadsen, René, Kim, Jiyoung, Rønnov-Jessen, Lone & Petersen, Ole William, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. p. 412 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen
Rønnov-Jessen, Lone, Kim, Jiyoung, Goldhammer, N., Klitgaard, M. C., Smicius, M., Bechmann, M. B., Villadsen, René & Petersen, Ole William, 2021, In: Scientific Reports. 11, 7 p., 17232.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-β1-mediated conversion of fibroblasts to myofibroblasts
Rønnov-Jessen, Lone, Villadsen, René, Edwards, J. C. & Petersen, Ole William, 2002, In: American Journal of Pathology. 161, 2, p. 471-480 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endothelial induced EMT in breast epithelial cells with stem cell properties
Sigurdsson, V., Hilmarsdottir, B., Sigmundsdottir, H., Fridriksdottir, A. J. R., Ringnér, M., Villadsen, René, Borg, A., Agnarsson, B. A., Petersen, Ole William, Magnusson, M. K. & Gudjonsson, T., 2011, In: P L o S One. 6, 9, p. e23833Research output: Contribution to journal › Journal article › Research › peer-review
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Annexin A8 Is Up-Regulated During Mouse Mammary Gland Involution and Predicts Poor Survival in Breast Cancer
Stein, T., Price, K. N., Morris, J. S., Heath, V. J., Ferrier, R. K., Bell, A. K., Pringle, M., Villadsen, René, Petersen, Ole William, Sauter, G., Bryson, G., Mallon, E. A. & Gusterson, B. A., 2005, In: Clinical Cancer Research. 11, p. 6872-6879Research output: Contribution to journal › Journal article › Research › peer-review
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Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells
Vaapil, M., Helczynska, K., Villadsen, René, Petersen, Ole William, Johansson, E., Beckman, S., Larsson, C., Påhlman, S. & Jögi, A., 2012, In: P L o S One. 7, 9, p. e46543Research output: Contribution to journal › Journal article › Research › peer-review
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Complete loss of wild-type TP53 in a nontransformed human epithelial cell line is preceded by a phase during which a heterozygous TP53 mutant effectively outgrows the homozygous wild-type cells
Villadsen, René, Nielsen, K. V., Bolund, L. & Briand, P., 1 Jan 2000, In: Cancer Genetics and Cytogenetics. 116, 1, p. 28-34 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In search of a stem cell hierarchy in the human breast and its relevance to breast cancer evolution
Villadsen, René, Nov 2005, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 113, 11-12, p. 903-21 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Evidence for a stem cell hierarchy in the adult human breast
Villadsen, René, Fridriksdottir, A. J., Rønnov-Jessen, Lone, Gudjonsson, T., Rank, F., LaBarge, M. A., Bissell, M. J. & Petersen, Ole William, 2007, In: Journal of Cell Biology. 177, 1, p. 87-101 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors
Ísberg, Ó. G., Kim, Jiyoung, Fridriksdottir, A. J., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, Lone, Petersen, Ole William & Villadsen, René, 2019, In: Scientific Reports. 9, 11 p., 14843.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4354
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Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
243
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Evidence of two distinct functionally specialized fibroblast lineages in breast stroma
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
219
downloads
Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Published