WinFood data from Kenya and Cambodia: constraints on field procedures
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WinFood data from Kenya and Cambodia : constraints on field procedures. / Owino, Victor O; Skau, Jutta Kloppenborg Heick; Omollo, Selina; Konyole, Silvenus; Kinyuru, John; Estambale, Benson; Owuor, Bethwel; Roos, Nanna; Friis, Henrik; WinFood Project Team.
In: Food and Nutrition Bulletin, Vol. 36, No. Suppl. 1, 2015, p. S41-S46.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - WinFood data from Kenya and Cambodia
T2 - constraints on field procedures
AU - Owino, Victor O
AU - Skau, Jutta Kloppenborg Heick
AU - Omollo, Selina
AU - Konyole, Silvenus
AU - Kinyuru, John
AU - Estambale, Benson
AU - Owuor, Bethwel
AU - Roos, Nanna
AU - Friis, Henrik
AU - WinFood Project Team
N1 - CURIS 2015 NEXS 147
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Researchers face myriad challenges in the design and implementation of randomized, controlled trials. Apart from summaries on limitations, these challenges are rarely documented in detail to inform future research projects.OBJECTIVE: To describe methodological challenges encountered during randomized, controlled trials (WinFood Study) designed to assess the efficacy of locally produced complementary foods based on traditional animal-source foods (edible termites and spiders) to support growth and nutritional status in Kenyan and Cambodian infants.METHODS: In a randomized, controlled design, infants received WinFood or corn-soy blend (CSB) for 9 months from 6 to 15 months of age. Lean mass accrual and blood nutrition indicators (lipid profile, iron and zinc status) were measured cross-sectionally at 9 and 15 months of age, respectively. Lean mass was determined by measuring deuterium oxide enrichment in saliva samples following a standard dose of deuterium solution (0.5 g/kg body weight) to infants. Blood nutrition indicators were determined following the drawing of 3 mL of blood by venipuncture.RESULTS: Challenges included rapid depletion of food rations, high rate of loss to follow-up, delayed ethical approval, lack of local food-processing capacity, low capacity among staff to draw blood, and lack of laboratory capacity to perform both deuterium oxide and micronutrient status measurements. Spillage of deuterium oxide solution during dosing was a major challenge in the Kenya context. A high rate of morbidity among infants made some assessments very difficult, especially drawing of blood and saliva samples.CONCLUSIONS: The challenges were largely contextual. Improvement of local laboratory capacity, training of staff and sensitization of the communities and the Ethics Review Committee are highly recommended.
AB - BACKGROUND: Researchers face myriad challenges in the design and implementation of randomized, controlled trials. Apart from summaries on limitations, these challenges are rarely documented in detail to inform future research projects.OBJECTIVE: To describe methodological challenges encountered during randomized, controlled trials (WinFood Study) designed to assess the efficacy of locally produced complementary foods based on traditional animal-source foods (edible termites and spiders) to support growth and nutritional status in Kenyan and Cambodian infants.METHODS: In a randomized, controlled design, infants received WinFood or corn-soy blend (CSB) for 9 months from 6 to 15 months of age. Lean mass accrual and blood nutrition indicators (lipid profile, iron and zinc status) were measured cross-sectionally at 9 and 15 months of age, respectively. Lean mass was determined by measuring deuterium oxide enrichment in saliva samples following a standard dose of deuterium solution (0.5 g/kg body weight) to infants. Blood nutrition indicators were determined following the drawing of 3 mL of blood by venipuncture.RESULTS: Challenges included rapid depletion of food rations, high rate of loss to follow-up, delayed ethical approval, lack of local food-processing capacity, low capacity among staff to draw blood, and lack of laboratory capacity to perform both deuterium oxide and micronutrient status measurements. Spillage of deuterium oxide solution during dosing was a major challenge in the Kenya context. A high rate of morbidity among infants made some assessments very difficult, especially drawing of blood and saliva samples.CONCLUSIONS: The challenges were largely contextual. Improvement of local laboratory capacity, training of staff and sensitization of the communities and the Ethics Review Committee are highly recommended.
U2 - 10.1177/15648265150361S107
DO - 10.1177/15648265150361S107
M3 - Journal article
C2 - 25902613
VL - 36
SP - S41-S46
JO - Food and Nutrition Bulletin
JF - Food and Nutrition Bulletin
SN - 0379-5721
IS - Suppl. 1
ER -
ID: 136850229