Vitamin A-induced cholestatic hepatitis: A case report
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Vitamin A-induced cholestatic hepatitis : A case report. / Becker, P; Maurer, B; Schirmacher, P; Waldherr, R; Parlesak, Alexandr; Bode, Cristiana; Seitz, Helmut Karl.
In: Zeitschrift fur Gastroenterologie, Vol. 45, No. 10, 2007, p. 1063-1066.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Vitamin A-induced cholestatic hepatitis
T2 - A case report
AU - Becker, P
AU - Maurer, B
AU - Schirmacher, P
AU - Waldherr, R
AU - Parlesak, Alexandr
AU - Bode, Cristiana
AU - Seitz, Helmut Karl
N1 - (Ekstern)
PY - 2007
Y1 - 2007
N2 - We report a case of intrahepatic cholestasis due to chronic vitamin A supplementation. A 70-year-old woman was admitted to the hospital for jaundice and reduced nutritional and general status with a 2-month history of increasing cholestasis. Some years previously she had suffered from breast and ovarian cancer with subsequent surgery and chemotherapy. Chemotherapy was terminated one month before elevated serum transaminase activities and cholestatic serum markers were noted. Following the chemotherapy, supportive care included weekly vitamin A injections (100 000 IU per injection). Liver biopsy showed an acute toxic liver injury with focal parenchymal necrosis, sinusoidal lesions, inflammatory infiltrate (round cells, macrophages), and activation and proliferation of stellate cells. The hepatic vitamin A concentration was found to be significantly elevated. There were no signs of intrahepatic metastasis or liver cirrhosis. Treatment with ursodeoxycholic acid rapidly improved the cholestasis and led to a total recovery after three weeks.
AB - We report a case of intrahepatic cholestasis due to chronic vitamin A supplementation. A 70-year-old woman was admitted to the hospital for jaundice and reduced nutritional and general status with a 2-month history of increasing cholestasis. Some years previously she had suffered from breast and ovarian cancer with subsequent surgery and chemotherapy. Chemotherapy was terminated one month before elevated serum transaminase activities and cholestatic serum markers were noted. Following the chemotherapy, supportive care included weekly vitamin A injections (100 000 IU per injection). Liver biopsy showed an acute toxic liver injury with focal parenchymal necrosis, sinusoidal lesions, inflammatory infiltrate (round cells, macrophages), and activation and proliferation of stellate cells. The hepatic vitamin A concentration was found to be significantly elevated. There were no signs of intrahepatic metastasis or liver cirrhosis. Treatment with ursodeoxycholic acid rapidly improved the cholestasis and led to a total recovery after three weeks.
KW - Cholestasis
KW - Hepatitis
KW - Vitamin A
U2 - 10.1055/s-2007-963342
DO - 10.1055/s-2007-963342
M3 - Journal article
C2 - 17924304
AN - SCOPUS:36048933961
VL - 45
SP - 1063
EP - 1066
JO - Zeitschrift fur Gastroenterologie
JF - Zeitschrift fur Gastroenterologie
SN - 0044-2771
IS - 10
ER -
ID: 322183868