Introduction: Most patients need rehabilitation after surgery for Colorectal Cancer and early mobilization is recommended. The purpose of the study was to assess the feasibility of using Virtual Reality (VR) in early mobilization of patients after surgery. Methods: Co-creation was used to design and develop VR software to the specific user needs of the patients using gamification methods. The study was designed to assess safety, comfort, and engagement of patients. Eleven patients who had undergone surgery for Colorectal Cancer played the game twice, no later than seven days after surgery. Results: No side effects, such as increased pain, dizziness, falls or affected general wellbeing, were detected and all patients found the game entertaining. Conclusion: VR for rehabilitation after surgery for Colorectal Cancer is safe and shows the potential to increase postoperative activity. To ensure patient engagement in training over time, development of games dedicated for this patient group is needed.