Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months
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Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months. / Katzenstein, T L; Ullum, H; Røge, Birgit T; Wandall, J; Dickmeiss, E; Barrington, T; Skinhøj, P; Gerstoft, J.
In: HIV Medicine, Vol. 4, No. 1, 01.2003, p. 53-61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months
AU - Katzenstein, T L
AU - Ullum, H
AU - Røge, Birgit T
AU - Wandall, J
AU - Dickmeiss, E
AU - Barrington, T
AU - Skinhøj, P
AU - Gerstoft, J
PY - 2003/1
Y1 - 2003/1
N2 - OBJECTIVE: To quantify HIV-RNA in plasma, in lymphoid tissue and proviral DNA in peripheral blood mononuclear cells and to relate these to immunological markers among patients with plasma viral load counts of METHODS: A prospective study of one hundred and three patients was undertaken with an inclusion criteria of plasma viral load of RESULTS: The median plasma viral load was < 20 copies/mL with no increase during follow-up. Thirty-one per cent had plasma viral load of /= 1 measurement with 21-200 and 25% had >/= 1 sample with plasma HIV-RNA > 200 copies/mL. Lymphoid tissue viral load was low at enrolment and declined further during follow-up. Baseline HIV-DNA and immunoglobulin (IgA) differed significantly between the plasma viral load rebound groups (P < 0.05).CONCLUSION: In this cohort, selected solely on the basis of having a plasma viral load of
AB - OBJECTIVE: To quantify HIV-RNA in plasma, in lymphoid tissue and proviral DNA in peripheral blood mononuclear cells and to relate these to immunological markers among patients with plasma viral load counts of METHODS: A prospective study of one hundred and three patients was undertaken with an inclusion criteria of plasma viral load of RESULTS: The median plasma viral load was < 20 copies/mL with no increase during follow-up. Thirty-one per cent had plasma viral load of /= 1 measurement with 21-200 and 25% had >/= 1 sample with plasma HIV-RNA > 200 copies/mL. Lymphoid tissue viral load was low at enrolment and declined further during follow-up. Baseline HIV-DNA and immunoglobulin (IgA) differed significantly between the plasma viral load rebound groups (P < 0.05).CONCLUSION: In this cohort, selected solely on the basis of having a plasma viral load of
KW - Adult
KW - Aged
KW - Anti-HIV Agents
KW - Antiretroviral Therapy, Highly Active
KW - CD4 Lymphocyte Count
KW - DNA, Viral
KW - Female
KW - Follow-Up Studies
KW - HIV
KW - HIV Infections
KW - Humans
KW - Immunoglobulin A
KW - Lymphoid Tissue
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Prospective Studies
KW - Proviruses
KW - RNA, Viral
KW - Viral Load
KW - Viremia
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Journal article
C2 - 12534960
VL - 4
SP - 53
EP - 61
JO - HIV Medicine
JF - HIV Medicine
SN - 1464-2662
IS - 1
ER -
ID: 180571437