Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. / Müllner, Elisabeth; Brath, Helmut; Pleifer, Simone; Schiermayr, Christiane; Baierl, Andreas; Wallner, Marlies; Fastian, Theresia; Millner, Yvonne; Paller, Kristina; Henriksen, Trine; Poulsen, Henrik Enghusen; Forster, Ernst; Wagner, Karl-Heinz.

In: Molecular Nutrition & Food Research, Vol. 57, No. 2, 2013, p. 328-338.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Müllner, E, Brath, H, Pleifer, S, Schiermayr, C, Baierl, A, Wallner, M, Fastian, T, Millner, Y, Paller, K, Henriksen, T, Poulsen, HE, Forster, E & Wagner, K-H 2013, 'Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes', Molecular Nutrition & Food Research, vol. 57, no. 2, pp. 328-338. https://doi.org/10.1002/mnfr.201200343

APA

Müllner, E., Brath, H., Pleifer, S., Schiermayr, C., Baierl, A., Wallner, M., Fastian, T., Millner, Y., Paller, K., Henriksen, T., Poulsen, H. E., Forster, E., & Wagner, K-H. (2013). Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. Molecular Nutrition & Food Research, 57(2), 328-338. https://doi.org/10.1002/mnfr.201200343

Vancouver

Müllner E, Brath H, Pleifer S, Schiermayr C, Baierl A, Wallner M et al. Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. Molecular Nutrition & Food Research. 2013;57(2):328-338. https://doi.org/10.1002/mnfr.201200343

Author

Müllner, Elisabeth ; Brath, Helmut ; Pleifer, Simone ; Schiermayr, Christiane ; Baierl, Andreas ; Wallner, Marlies ; Fastian, Theresia ; Millner, Yvonne ; Paller, Kristina ; Henriksen, Trine ; Poulsen, Henrik Enghusen ; Forster, Ernst ; Wagner, Karl-Heinz. / Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes. In: Molecular Nutrition & Food Research. 2013 ; Vol. 57, No. 2. pp. 328-338.

Bibtex

@article{bbb57ebb79b04ece8c34976ea14b3df6,
title = "Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes",
abstract = "SCOPE: Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics. METHODS AND RESULTS: Seventy-six diabetic and 21 nondiabetic individuals participated in this study. All subjects received information about the benefits of a healthy diet, while subjects randomly assigned to the intervention group received additionally 300 g of vegetables and 25 mL PUFA-rich plant oil per day. DNA damage in mononuclear cells (Comet Assay), urinary excretion of 8-oxo-7-hydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and glycated hemoglobin (HbA1c) were measured at baseline, after 4, 8 (end of intervention), and 16 weeks. The intervention with vegetables and PUFA-rich oil led to a significant increase in plasma antioxidant concentrations. Diabetic individuals of the intervention group showed a significant reduction in HbA1c and DNA strand breaks. Levels of HbA1c were also improved in diabetics of the information group, but oxidative damage to DNA was not altered. Urinary 8-oxodG and 8-oxoGuo excretion remained unchanged in both groups. CONCLUSIONS: This study provides evidence that a healthy diet rich in antioxidants reduces levels of DNA strand breaks in diabetic individuals.",
author = "Elisabeth M{\"u}llner and Helmut Brath and Simone Pleifer and Christiane Schiermayr and Andreas Baierl and Marlies Wallner and Theresia Fastian and Yvonne Millner and Kristina Paller and Trine Henriksen and Poulsen, {Henrik Enghusen} and Ernst Forster and Karl-Heinz Wagner",
note = "{\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2013",
doi = "10.1002/mnfr.201200343",
language = "English",
volume = "57",
pages = "328--338",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH",
number = "2",

}

RIS

TY - JOUR

T1 - Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes

AU - Müllner, Elisabeth

AU - Brath, Helmut

AU - Pleifer, Simone

AU - Schiermayr, Christiane

AU - Baierl, Andreas

AU - Wallner, Marlies

AU - Fastian, Theresia

AU - Millner, Yvonne

AU - Paller, Kristina

AU - Henriksen, Trine

AU - Poulsen, Henrik Enghusen

AU - Forster, Ernst

AU - Wagner, Karl-Heinz

N1 - © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2013

Y1 - 2013

N2 - SCOPE: Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics. METHODS AND RESULTS: Seventy-six diabetic and 21 nondiabetic individuals participated in this study. All subjects received information about the benefits of a healthy diet, while subjects randomly assigned to the intervention group received additionally 300 g of vegetables and 25 mL PUFA-rich plant oil per day. DNA damage in mononuclear cells (Comet Assay), urinary excretion of 8-oxo-7-hydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and glycated hemoglobin (HbA1c) were measured at baseline, after 4, 8 (end of intervention), and 16 weeks. The intervention with vegetables and PUFA-rich oil led to a significant increase in plasma antioxidant concentrations. Diabetic individuals of the intervention group showed a significant reduction in HbA1c and DNA strand breaks. Levels of HbA1c were also improved in diabetics of the information group, but oxidative damage to DNA was not altered. Urinary 8-oxodG and 8-oxoGuo excretion remained unchanged in both groups. CONCLUSIONS: This study provides evidence that a healthy diet rich in antioxidants reduces levels of DNA strand breaks in diabetic individuals.

AB - SCOPE: Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics. METHODS AND RESULTS: Seventy-six diabetic and 21 nondiabetic individuals participated in this study. All subjects received information about the benefits of a healthy diet, while subjects randomly assigned to the intervention group received additionally 300 g of vegetables and 25 mL PUFA-rich plant oil per day. DNA damage in mononuclear cells (Comet Assay), urinary excretion of 8-oxo-7-hydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and glycated hemoglobin (HbA1c) were measured at baseline, after 4, 8 (end of intervention), and 16 weeks. The intervention with vegetables and PUFA-rich oil led to a significant increase in plasma antioxidant concentrations. Diabetic individuals of the intervention group showed a significant reduction in HbA1c and DNA strand breaks. Levels of HbA1c were also improved in diabetics of the information group, but oxidative damage to DNA was not altered. Urinary 8-oxodG and 8-oxoGuo excretion remained unchanged in both groups. CONCLUSIONS: This study provides evidence that a healthy diet rich in antioxidants reduces levels of DNA strand breaks in diabetic individuals.

U2 - 10.1002/mnfr.201200343

DO - 10.1002/mnfr.201200343

M3 - Journal article

C2 - 23148048

VL - 57

SP - 328

EP - 338

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 2

ER -

ID: 48556762